Literature DB >> 3012924

The GABAergic control of prolactin release is not affected by insulin-dependent diabetes mellitus: evidence from studies with sodium valproate.

V Coiro, C Davoli, R Volpi, E Sorini, E Voltini, G Rossi, R Delsignore, A Gnudi, P Chiodera.   

Abstract

In order to evaluate the influence of the GABAergic system in the regulation of PRL secretion in patients with IDDM, serum PRL levels were measured in 7 diabetics and in 7 normal men with sodium valproate (400 mg per os), a drug capable of increasing cerebral GABA concentrations. A significant decrease of serum PRL concentrations was observed between 30 and 120 min after sodium valproate administration in both control and diabetic subjects. The time course and magnitude of the sodium valproate effect were similar in all subjects. These data confirm the inhibitory control of the GABAergic system on PRL secretion in man as evidenced by the GABAergic drug sodium valproate. It is suggested that this system is not altered in diabetic patients.

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Year:  1986        PMID： 3012924     DOI： 10.1007/bf02581354

Source DB:  PubMed          Journal:  Acta Diabetol Lat        ISSN： 0001-5563


  19 in total

1.  A homologous radioimmunoassay for human prolactin.

Authors:  Y N Sinha; F W Selby; U J Lewis; W P VanderLaan
Journal:  J Clin Endocrinol Metab       Date:  1973-03       Impact factor: 5.958

Review 2.  Regulatory role of gamma-aminobutyric acid in pituitary hormone secretion.

Authors:  A N Elias; L J Valenta; A V Szekeres; M K Grossman
Journal:  Psychoneuroendocrinology       Date:  1982       Impact factor: 4.905

3.  Failure of naloxone to modify anterior pituitary secretory pattern in insulin-dependent diabetics.

Authors:  P Chiodera; R Volpi; V Coiro; L Camellini; G Rossi; D Pignatti; E Roti
Journal:  Horm Metab Res       Date:  1984-01       Impact factor: 2.936

4.  [Blood prolactin in insulin-dependent diabetics. Basal study and effect of stimulation].

Authors:  J Champeyroux; S Moinade; G Gaillard; D Boucher
Journal:  Nouv Presse Med       Date:  1978-03-25

5.  Possible altered dopaminergic modulation of pituitary function in normal-menstruating women with insulin dependent diabetes mellitus (IDDM).

Authors:  H Djursing; L Carstensen; C Hagen; A N Andersen
Journal:  Acta Endocrinol (Copenh)       Date:  1984-12

6.  Hyperprolactinaemia in male diabetics.

Authors:  A D Mooradian; J E Morley; C J Billington; M F Slag; M K Elson; R B Shafer
Journal:  Postgrad Med J       Date:  1985-01       Impact factor: 2.401

7.  [Pituitary-gonadal function in male diabetic patients (author's transl)].

Authors:  A Cailleba; S Moinade; G Gaillard; D Boucher
Journal:  Nouv Presse Med       Date:  1982-04-17

8.  Abnormal conjugated dopamine levels in patients with normoprolactinaemic amenorrhoea and in insulin-dependent diabetic patients.

Authors:  C Hagen; H Djursing; N J Christensen; A N Andersen; K Tvede; K Petersen; L Carstensen
Journal:  Scand J Clin Lab Invest       Date:  1985-09       Impact factor: 1.713

9.  Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus.

Authors:  H Djursing; C Hagen; H C Nyholm; L Carstensen; A N Andersen
Journal:  J Clin Endocrinol Metab       Date:  1983-05       Impact factor: 5.958

10.  Growth hormone, prolactin and thyrotrophin responses to thyrotrophin-releasing hormone in diabetic patients.

Authors:  A D Harrower
Journal:  Postgrad Med J       Date:  1980-07       Impact factor: 2.401
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