| Literature DB >> 30129227 |
Yao Ge1,2, Zhaobin Han1, Zheng Wang1, Chen-Guo Feng1, Qian Zhao3, Guo-Qiang Lin1, Kuiling Ding1,2,4.
Abstract
The first asymmetric hydrogenation of 3-ylidenephthalides has been developed using the IrI complex of a spiro[4,4]-1,6-nonadiene-based phosphine-oxazoline ligand (SpinPHOX) as the catalyst, affording a wide variety of chiral 3-substituted phthalides in excellent enantiomeric excesses (up to 98 % ee). The utility of the protocol has been demonstrated in the asymmetric synthesis of chiral drugs NBP and BZP precursor, as well as the natural products chuangxinol and typhaphthalide.Entities:
Keywords: P, N ligands; asymmetric catalysis; hydrogenation; iridium; phthalides
Year: 2018 PMID： 30129227 DOI： 10.1002/anie.201807639
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336