| Literature DB >> 30129206 |
Benedict Seddon1, Andrew J Yates2.
Abstract
Generating and maintaining a diverse repertoire of naive T cells is essential for protection against pathogens, and developing a mechanistic and quantitative description of the processes involved lies at the heart of our understanding of vertebrate immunity. Here, we review the biology of naive T cells from birth to maturity and outline how the integration of mathematical models and experiments has helped us to develop a full picture of their life histories.Keywords: T cells; mathematical modeling; thymic development
Mesh:
Year: 2018 PMID: 30129206 DOI: 10.1111/imr.12694
Source DB: PubMed Journal: Immunol Rev ISSN: 0105-2896 Impact factor: 12.988