Anti-Condyloma acuminata mechanism of microRNAs-375 modulates HPV in cervical cancer cells via the UBE3A and IGF-1R pathway.

The present study aimed to identify the probable anti-Condyloma acuminata (CA) mechanism of microRNA-375 (miRNA-375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA-375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV-18(+) cervical cancer cells. The overexpression of miRNA-375 significantly increased caspase-3 and caspase-9 activities, induced B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein, tumor protein 53 and cyclin-dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV-18(+) cervical cancer cells. The overexpression of miRNA-375 significantly suppressed the levels of protein expression of ubiquitin-protein ligase E3A (UBE3A) and Insulin-like growth factor-1 receptor (IGF-1R) in HPV-18(+) cervical cancer cells. To conclude, it was identified that the probable anti-CA mechanism of miRNA-375 modulates HPV through the UBE3A and IGF-1R pathway in cervical cancer cells.