| Literature DB >> 30127554 |
Uday Yanamandra1, Parathan Karunakaran2, Alka Khadwal2, Gaurav Prakash2, Deepesh Lad2, Shano Naseem3, Neelam Varma3, Arunaloke Chakrabarti4, Subhash Varma2, Pankaj Malhotra2.
Abstract
Invasive fungal infection (IFI) in patients with acute promyelocytic leukemia (APL) is a common phenomenon in developing countries. In a systematic study (Dual Inducing Differentiating agents-Indian Trial: DID-IT) using dual differentiating agents (ATO and ATRA) in 98 APL patients at our center we report 18.3% incidence of IFI (n-18). Among all cases of IFI three were definitive, 14 were probable and one was possible IFI. We conclude that incidence of IFI in APL is affected by environmental and therapy related factors and mere usage of dual differentiating agents need not necessarily decrease the incidence of fungal infections.Entities:
Keywords: APL; ATO; ATRA; Fungal infection
Year: 2017 PMID: 30127554 PMCID: PMC6081339 DOI: 10.1007/s12288-017-0894-9
Source DB: PubMed Journal: Indian J Hematol Blood Transfus ISSN: 0971-4502 Impact factor: 0.900