Literature DB >> 30125723

β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities.

Jiangkun Dai1, Wenjia Dan1, Uwe Schneider2, Junru Wang3.   

Abstract

β-Carboline alkaloids are a family of natural and synthetic products with great structural diversity and outstanding biological activities. This review covers critically important developments in the field of β-carbolines, predominantly over the past decade (2006-2017.7). It is focused on both natural and synthetic monomers as well as dimers, and includes key information on occurrence, structural diversity, and biological activities. In the cases where sufficient information is available, structure-activity relationship (SAR) and mechanism of their biological activities were presented. In addition, innovative syntheses of the β-carboline core and potential future directions have been discussed.
Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Biological activity; Dimer; Mechanism; Monomer; Occurrence; SAR; Structural diversity; β-Carboline

Mesh：

Substances：

Year:  2018        PMID： 30125723     DOI： 10.1016/j.ejmech.2018.08.027

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  13 in total

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