Elizabeth A Godbey1, Joseph Schwartz2. 1. Virginia Commonwealth University Health System, Richmond, Virginia, USA. 2. Columbia University Irving Medical Center, New York, New York, USA.
Abstract
PURPOSE OF REVIEW: We review recent articles pertaining to the use of tranexamic acid (TXA) in populations at risk for massive transfusion. Although there are no recent studies that specifically examine the use of TXA in massive transfusion protocols (MTPs), there are a few studies with subgroups of massive transfusion patients. RECENT FINDINGS: In recent years, many publications have discussed outcomes and safety associated with the addition of TXA to treatment plans for bleeding pediatric, trauma, and postpartum hemorrhage patients. In general, TXA appears to decrease mortality and transfusion requirements. SUMMARY: TXA was shown to decrease mortality in several bleeding populations. It is now a common addition to MTPs. There is conflicting evidence regarding the potential of TXA as a risk factor for thrombotic events. Ongoing studies should provide additional evidence regarding the thrombotic risk of TXA in massive transfusion.
PURPOSE OF REVIEW: We review recent articles pertaining to the use of tranexamic acid (TXA) in populations at risk for massive transfusion. Although there are no recent studies that specifically examine the use of TXA in massive transfusion protocols (MTPs), there are a few studies with subgroups of massive transfusion patients. RECENT FINDINGS: In recent years, many publications have discussed outcomes and safety associated with the addition of TXA to treatment plans for bleeding pediatric, trauma, and postpartum hemorrhagepatients. In general, TXA appears to decrease mortality and transfusion requirements. SUMMARY:TXA was shown to decrease mortality in several bleeding populations. It is now a common addition to MTPs. There is conflicting evidence regarding the potential of TXA as a risk factor for thrombotic events. Ongoing studies should provide additional evidence regarding the thrombotic risk of TXA in massive transfusion.
Authors: Claire Tucker; Anna Winner; Ryan Reeves; Edward S Cooper; Kelly Hall; Julie Schildt; David Brown; Julien Guillaumin Journal: Front Vet Sci Date: 2022-01-05