Tanveer A Tabish1, Chris J Scotton2, Daniel CJ Ferguson2, Liangxu Lin1, Anienke van der Veen2, Sophie Lowry2, Muhammad Ali4, Farhat Jabeen3, Muhammad Ali4, Paul G Winyard2, Shaowei Zhang1. 1. Centre for Graphene Science, College of Engineering, Mathematics & Physical Sciences, University of Exeter, Stocker Road, Exeter, EX4 4QF UK. 2. Institute of Biomedical & Clinical Science, University of Exeter Medical School, St Luke's Campus, Exeter, EX1 2LU, UK. 3. Department of Zoology, Government College University, Faisalabad, 38000, Pakistan. 4. Faculty of Animal Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
Abstract
AIM: Achieving reliably high production of reactive oxygen species (ROS) in photodynamic therapy (PDT) remains challenging. Graphene quantum dots (GQDs) hold great promise for PDT. However, the photochemical processes leading to GQD-derived ROS generation have not yet been fully elucidated. MATERIALS & METHODS: Physicochemical characteristics of GQDs were comprehensively investigated, including electron paramagnetic resonance analysis of singlet oxygen production. Dark toxicity was assessed in vitro and in vivo. RESULTS: GQDs demonstrated excellent photoluminescent features, corrosion resistance, high water solubility, high photo/pH-stability, in vitro and in vivo biocompatibility and very efficient singlet oxygen/ROS generation. CONCLUSION: The enhanced ROS generation, combined with good biocompatibility and minimal toxicity in vitro and in vivo support the potential of GQDs for future PDT application.
AIM: Achieving reliably high production of reactive oxygen species (ROS) in photodynamic therapy (PDT) remains challenging. Graphene quantum dots (GQDs) hold great promise for PDT. However, the photochemical processes leading to GQD-derived ROS generation have not yet been fully elucidated. MATERIALS & METHODS: Physicochemical characteristics of GQDs were comprehensively investigated, including electron paramagnetic resonance analysis of singlet oxygen production. Dark toxicity was assessed in vitro and in vivo. RESULTS: GQDs demonstrated excellent photoluminescent features, corrosion resistance, high water solubility, high photo/pH-stability, in vitro and in vivo biocompatibility and very efficient singlet oxygen/ROS generation. CONCLUSION: The enhanced ROS generation, combined with good biocompatibility and minimal toxicity in vitro and in vivo support the potential of GQDs for future PDT application.
Authors: Tanveer A Tabish; Md Zahidul I Pranjol; David W Horsell; Alma A M Rahat; Jacqueline L Whatmore; Paul G Winyard; Shaowei Zhang Journal: Cancers (Basel) Date: 2019-03-06 Impact factor: 6.639