Matthieu Carton1, Gwenn Menvielle2, Diane Cyr3,4, Marie Sanchez5,6, Corinne Pilorget7,8, Anne-Valérie Guizard9, Isabelle Stücker5,6, Danièle Luce10. 1. Institut Curie, PSL Research University, DRCI, Biométrie, Saint-Cloud, France. 2. Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France. 3. Inserm, Population-based Epidemiologic Cohorts Unit, Villejuif, France. 4. University of Versailles St-Quentin, Villejuif, France. 5. Inserm, CESP Centre for research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif, France. 6. University Paris-Sud, Villejuif, France. 7. French Institute for Public Health Surveillance, Department of Occupational Health, Saint Maurice, France. 8. UMRESTTE (Epidemiological Research and Surveillance Unit in Transport, Occupation and Environment), University Claude Bernard, Lyon, France. 9. Calvados Cancer Registry, Caen, France. 10. Inserm U 1085-Institut de Recherche Santé Environnement & Travail (IRSET), Faculté de Médecine, Pointe-à-Pitre, France.
Abstract
BACKGROUND: To investigate the association between head and neck squamous cell cancer (HNSCC) risk and occupational exposure to flour dust in women and men, using data from ICARE, a French population-based case-control study. METHODS: The analysis included 2053 cases of HNSCC and 3507 controls. Lifelong occupational history was collected. A job-exposure matrix was used to assess exposure to flour dust. Odds-ratios (ORs) and 95% confidence intervals (CI), adjusted for smoking, alcohol drinking, and asbestos exposure, were estimated with logistic regression models. RESULTS: Ever exposure to flour dust was associated with elevated ORs in women (OR = 2.15, 95%CI: 1.01 4.55) and in men (OR = 1.55, 95%CI: 1.11 2.17). In women, the risk increased with the probability, the duration, and the cumulative level of exposure. No dose-response relationships were observed in men. CONCLUSIONS: Although the results were less conclusive in men than in women, overall, these findings provide some support to the hypothesis of a role of flour dust in the occurrence of HNSCC.
BACKGROUND: To investigate the association between head and neck squamous cell cancer (HNSCC) risk and occupational exposure to flour dust in women and men, using data from ICARE, a French population-based case-control study. METHODS: The analysis included 2053 cases of HNSCC and 3507 controls. Lifelong occupational history was collected. A job-exposure matrix was used to assess exposure to flour dust. Odds-ratios (ORs) and 95% confidence intervals (CI), adjusted for smoking, alcohol drinking, and asbestos exposure, were estimated with logistic regression models. RESULTS: Ever exposure to flour dust was associated with elevated ORs in women (OR = 2.15, 95%CI: 1.01 4.55) and in men (OR = 1.55, 95%CI: 1.11 2.17). In women, the risk increased with the probability, the duration, and the cumulative level of exposure. No dose-response relationships were observed in men. CONCLUSIONS: Although the results were less conclusive in men than in women, overall, these findings provide some support to the hypothesis of a role of flour dust in the occurrence of HNSCC.
Authors: Pierluigi Cocco; Giannina Satta; Federico Meloni; Ilaria Pilia; Fahad Ahmed; Nikolaus Becker; Delphine Casabonne; Silvia de Sanjosé; Lenka Foretova; Marc Maynadié; Alexandra Nieters; Anthony Staines; Andrea 't Mannetje; Mariagrazia Zucca; Maria Grazia Ennas; Marcello Campagna; Sara De Matteis; Yolanda Benavente Journal: Scand J Work Environ Health Date: 2020-09-25 Impact factor: 5.024