Carlos Henrique Ferreira Camargo1, Vinícius Aguiar Jobbins2, Rafael Arthur Serpa3, Frederico Antônio Berbetz4, Jivago Szpoganicz Sabatini5, Hélio Afonso Ghizoni Teive6. 1. Neurology Service, University Hospital, State University of Ponta Grossa, Ponta Grossa, Brazil. Electronic address: chcamargo@uol.com.br. 2. Neurology Service, University Hospital, State University of Ponta Grossa, Ponta Grossa, Brazil. Electronic address: jobbinsv@gmail.com. 3. Neurology Service, University Hospital, State University of Ponta Grossa, Ponta Grossa, Brazil. Electronic address: rafael.serpa@hotmail.com. 4. Neurology Service, University Hospital, State University of Ponta Grossa, Ponta Grossa, Brazil. Electronic address: fred.berbetz@hotmail.com. 5. Neurology Service, University Hospital, State University of Ponta Grossa, Ponta Grossa, Brazil. Electronic address: jivagosabatini@hotmail.com. 6. Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. Electronic address: hagteive@mps.com.br.
Abstract
OBJECTIVE: The aim of this study was to compare the cognitive deficits and olfaction in PD patients. PATIENTS AND METHODS: In all, 42 PD patients and 38 controls were selected. All the individuals in both groups underwent cognitive assessment with the SCOPA-Cog neuropsychological battery and Mini-Mental State Examination (MMSE) and olfactory assessment with the Sniffin' Sticks Screening 12 Test. Parkinson's disease dementia (PDD) was diagnosed using the International Parkinson and Movement Disorder Society (MDS) criteria. RESULTS: The prevalence of olfactory dysfunction in PD patients was 95.24% (40/42). There was no statistically significant difference in olfaction when compared to patients with PDD and PD without cognitive deficits (5.12 ± 3.25 vs. 6.71 ± 2.63, p = 0.115). Attention [r = 0.35, 95% CI = (0.05-0.59), p = 0.01] was the only cognitive domain correlated with olfactory loss in PD patients. There was a higher correlation among the scores of cognitive and olfactory assessments in controls, r=0.40 (95% CI = [0.09-0.64], p = 0.007), with MMSE. CONCLUSION: The olfactory deficits prevalence in PD patients was significantly high. There may be a correlation between frontal lobe dysfunction and olfactory deficit.
OBJECTIVE: The aim of this study was to compare the cognitive deficits and olfaction in PDpatients. PATIENTS AND METHODS: In all, 42 PDpatients and 38 controls were selected. All the individuals in both groups underwent cognitive assessment with the SCOPA-Cog neuropsychological battery and Mini-Mental State Examination (MMSE) and olfactory assessment with the Sniffin' Sticks Screening 12 Test. Parkinson's disease dementia (PDD) was diagnosed using the International Parkinson and Movement Disorder Society (MDS) criteria. RESULTS: The prevalence of olfactory dysfunction in PDpatients was 95.24% (40/42). There was no statistically significant difference in olfaction when compared to patients with PDD and PD without cognitive deficits (5.12 ± 3.25 vs. 6.71 ± 2.63, p = 0.115). Attention [r = 0.35, 95% CI = (0.05-0.59), p = 0.01] was the only cognitive domain correlated with olfactory loss in PDpatients. There was a higher correlation among the scores of cognitive and olfactory assessments in controls, r=0.40 (95% CI = [0.09-0.64], p = 0.007), with MMSE. CONCLUSION: The olfactory deficits prevalence in PDpatients was significantly high. There may be a correlation between frontal lobe dysfunction and olfactory deficit.
Authors: Boo-Young Kim; Ju Yeon Park; Eui Jin Kim; Byung Guk Kim; Sung Won Kim; Soo Whan Kim Journal: Int Forum Allergy Rhinol Date: 2019-02-21 Impact factor: 3.858