Yanlin Yin1, Xinwei Liu2, Xinming Yang3, Jie Guo2, Qiang Wang2, Lixing Chen4. 1. Orthopedics Department, The First Afiliated Hospital of Heibei North University, Zhangjiakou 075000, China. Electronic address: ylyyyl2005@163.com. 2. Spine Surgery, Second Hopsital of Zhangjiakou City, Zhangjiakou 075000, China. 3. Orthopedics Department, The First Afiliated Hospital of Heibei North University, Zhangjiakou 075000, China. 4. Faculty of Graduate Studies, HeBei North University, Zhangjiakou 075000, China.
Abstract
BACKGROUND CONTEXT: Spondylitis is a rare infection in bone requiring multiple diagnostic strategies for verification. PURPOSE: This study aimed to compare the diagnostic values of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in detecting spondylitis. METHODS: Online PubMed, Embase, and Cochrane Library databases were systematically searched through September 2017 for studies comparing the diagnostic values of 18F-FDG-PET and MRI. The summary sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were calculated using Stata software. The ratio of these indexes between 18F-FDG-PET and MRI was also determined. RESULTS: The summary results for 18F-FDG-PET were as follows: sensitivity=0.96 [95% confidence intervals (CI), 0.84-0.99]; specificity=0.90 (95% CI, 0.79-0.96); PLR=9.83 (95% CI, 4.39-22.03); NLR=0.05 (95% CI, 0.01-0.19); DOR=124.08 (95% CI, 39.04-394.34); and area under the SROC=0.97 (95% CI, 0.95-0.98). The summary sensitivity, specificity, PLR, NLR, DOR, and area under the SROC for MRI were 0.76 (95% CI, 0.65-0.84), 0.62 (95% CI, 0.45-0.77), 2.01 (95% CI, 1.36-2.98), 0.39 (95% CI, 0.27-0.56), 5.08 (95% CI, 2.66-9.69), and 0.77 (95% CI, 0.73-0.80), respectively. The summary results of sensitivity (p=.034), specificity (p=.006), PLR (p<.001), DOR (p<.001), and area under the SROC (p<.001) were higher in 18F-FDG-PET than in MRI. However, NLR (p=.003) was lower in 18F-FDG-PET than in MRI. CONCLUSIONS: 18F-FDG-PET had a higher diagnostic value compared with MRI in detecting spondylitis.
BACKGROUND CONTEXT: Spondylitis is a rare infection in bone requiring multiple diagnostic strategies for verification. PURPOSE: This study aimed to compare the diagnostic values of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in detecting spondylitis. METHODS: Online PubMed, Embase, and Cochrane Library databases were systematically searched through September 2017 for studies comparing the diagnostic values of 18F-FDG-PET and MRI. The summary sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were calculated using Stata software. The ratio of these indexes between 18F-FDG-PET and MRI was also determined. RESULTS: The summary results for 18F-FDG-PET were as follows: sensitivity=0.96 [95% confidence intervals (CI), 0.84-0.99]; specificity=0.90 (95% CI, 0.79-0.96); PLR=9.83 (95% CI, 4.39-22.03); NLR=0.05 (95% CI, 0.01-0.19); DOR=124.08 (95% CI, 39.04-394.34); and area under the SROC=0.97 (95% CI, 0.95-0.98). The summary sensitivity, specificity, PLR, NLR, DOR, and area under the SROC for MRI were 0.76 (95% CI, 0.65-0.84), 0.62 (95% CI, 0.45-0.77), 2.01 (95% CI, 1.36-2.98), 0.39 (95% CI, 0.27-0.56), 5.08 (95% CI, 2.66-9.69), and 0.77 (95% CI, 0.73-0.80), respectively. The summary results of sensitivity (p=.034), specificity (p=.006), PLR (p<.001), DOR (p<.001), and area under the SROC (p<.001) were higher in 18F-FDG-PET than in MRI. However, NLR (p=.003) was lower in 18F-FDG-PET than in MRI. CONCLUSIONS: 18F-FDG-PET had a higher diagnostic value compared with MRI in detecting spondylitis.
Authors: Giorgio Treglia; Mariarosa Pascale; Elena Lazzeri; Wouter van der Bruggen; Roberto C Delgado Bolton; Andor W J M Glaudemans Journal: Eur J Nucl Med Mol Imaging Date: 2019-11-15 Impact factor: 9.236