| Literature DB >> 30121215 |
Dongxiao Liang1, Li Shu1, Hongxu Pan1, Qian Xu2, Jifeng Guo3, Xinxiang Yan2, Beisha Tang4, Qiying Sun5.
Abstract
LRRK2 is the most common genetic cause of PD. G2385R and R1628 P variants are the most common variants of LRRK2 in Chinese populations. Consensus on the clinical features of G2385R and R1628 P related PD has not been reached yet, although it had been widely studied. In our study, genotype analyses were conducted on 721 PD patients of Chinese origin. A total of 62 G2385R carriers, 32 R1628 P carriers and 623 idiopathic PD patients underwent the following clinical feature analysis. Motor symptoms, non-motor symptoms and co-morbidities were the targeted features to be analyzed. As a result, Neither the G2385R nor the R1628 P carriers showed significant clinical feature differences when compared to the idiopathic PD patients, so did the comparison between the G2385R and the R1628 P carriers. In conclusion, the clinical features of PD patients with LRRK2 G2385R or R1628 P variants were similar to those of idiopathic PD.Entities:
Keywords: Clinical; LRRK2 G2385R; Parkinson’s disease; Phenotype; R1628P
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Year: 2018 PMID： 30121215 DOI： 10.1016/j.neulet.2018.08.015
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046