Literature DB >> 3012114

A conserved cis-acting sequence in the 5' leader of avian sarcoma virus RNA is required for packaging.

R A Katz, R W Terry, A M Skalka.   

Abstract

The deletion of a conserved sequence of ca. 30 nucleotides in the 5' noncoding leader region of an avian sarcoma virus DNA clone resulted in a loss of infectivity after transfection of chicken embryo fibroblasts. Genetic and biochemical analysis of a representative mutant demonstrated that the env gene was expressed normally. Thus, viral RNA transcription, splicing, and translation were not impaired. The amount of mutant viral RNA encapsidated into virions, however, was severely reduced despite the presence of helper-virus. We conclude that the deleted sequence is an essential cis-acting packaging signal.

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Year:  1986        PMID： 3012114      PMCID： PMC253052     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Microinjection analysis of envelope-glycoprotein messenger activities of avian leukosis viral RNAs.

Authors:  D W Stacey; V G Allfrey; H Hanafusa
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

2.  Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control.

Authors:  R A Katz; B R Cullen; R Malavarca; A M Skalka
Journal:  Mol Cell Biol       Date:  1986-02       Impact factor: 4.272

3.  Extracellular nucleases of pseudomonas BAL 31. III. Use of the double-strand deoxyriboexonuclease activity as the basis of a convenient method for the mapping of fragments of DNA produced by cleavage with restriction enzymes.

Authors:  R J Legerski; J L Hodnett; H B Gray
Journal:  Nucleic Acids Res       Date:  1978-05       Impact factor: 16.971

4.  Characteristics of two new avian tumor virus subgroups.

Authors:  R G Duff; P K Vogt
Journal:  Virology       Date:  1969-09       Impact factor: 3.616

5.  Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase.

Authors:  S Goff; P Traktman; D Baltimore
Journal:  J Virol       Date:  1981-04       Impact factor: 5.103

6.  Nucleotide sequence of Rous sarcoma virus.

Authors:  D E Schwartz; R Tizard; W Gilbert
Journal:  Cell       Date:  1983-03       Impact factor: 41.582

7.  The leader sequence of the subgenomic mRNA's of Rous sarcoma virus is approximately 390 nucleotides.

Authors:  P B Hackett; R Swanstrom; H E Varmus; J M Bishop
Journal:  J Virol       Date:  1982-02       Impact factor: 5.103

8.  Nucleotide sequence of the long terminal repeat and flanking cellular sequences of avian endogenous retrovirus ev-2: variation in Rous-associated virus-0 expression cannot be explained by differences in primary sequence.

Authors:  D R Scholl; S Kahn; R Malavarca; S Astrin; A M Skalka
Journal:  J Virol       Date:  1983-02       Impact factor: 5.103

9.  Messenger activity of virion RNA for avian leukosis viral envelope glycoprotein.

Authors:  D W Stacey
Journal:  J Virol       Date:  1979-03       Impact factor: 5.103

10.  Avian oncovirus mutant (SE21Q1b) deficient in genomic RNA: characterization of a deletion in the provirus.

Authors:  P R Shank; M Linial
Journal:  J Virol       Date:  1980-11       Impact factor: 5.103
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  82 in total

1.  Human immunodeficiency virus types 1 and 2 differ in the predominant mechanism used for selection of genomic RNA for encapsidation.

Authors:  J F Kaye; A M Lever
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

2.  A mutation in the short 5'-proximal open reading frame on Rous sarcoma virus RNA alters virus production.

Authors:  R B Petersen; A Moustakas; P B Hackett
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

3.  In vitro characterization of a base pairing interaction between the primer binding site and the minimal packaging signal of avian leukosis virus genomic RNA.

Authors:  Igor Kanevsky; Natalya Vasilenko; Hélène Dumay-Odelot; Philippe Fossé
Journal:  Nucleic Acids Res       Date:  2003-12-15       Impact factor: 16.971

4.  Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus.

Authors:  A Aldovini; R A Young
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

5.  RNA dimerization defect in a Rous sarcoma virus matrix mutant.

Authors:  L J Parent; T M Cairns; J A Albert; C B Wilson; J W Wills; R C Craven
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

6.  Development of avian sarcoma and leukosis virus-based vector-packaging cell lines.

Authors:  A W Stoker; M J Bissell
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

7.  Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein.

Authors:  J Luban; S P Goff
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

8.  An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences.

Authors:  E Vicenzi; D S Dimitrov; A Engelman; T S Migone; D F Purcell; J Leonard; G Englund; M A Martin
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

9.  Solution structure of the Rous sarcoma virus nucleocapsid protein: muPsi RNA packaging signal complex.

Authors:  Jing Zhou; Rebecca L Bean; Volker M Vogt; Michael Summers
Journal:  J Mol Biol       Date:  2006-10-10       Impact factor: 5.469

10.  Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA.

Authors:  J Luban; S P Goff
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103
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