Cátia Sofia da Costa Domingues1,2,3,4, Beatriz Prazeres Serambeque3,5, Mafalda Sofia Laranjo Cândido3,5,6, Carlos Miguel Machado Marto3,5,6,7, Francisco José de Baptista Veiga1,2,6, Ana Bela Sarmento Antunes Cruz Ribeiro3,4,6, Ana Rita Ramalho Figueiras1,2, Maria Filomena Roque Botelho3,5,6, Marília de Assunção Rodrigues Ferreira Dourado3,4,8. 1. Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. 2. REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. 3. CIMAGO, Center of Investigation on Environment Genetics and Oncobiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. 4. Laboratory of Oncobiology and Hematology (LOH) and University Clinic of Hematology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. 5. Biophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. 6. CNC/IBILI, Center for Neuroscience and Cell Biology, Institute for Biomedical Imaging and Life Sciences, University of Coimbra, Coimbra, Portugal. 7. Experimental Pathology Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. 8. Pathophysiology Course Unit, Dentistry Area, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Abstract
BACKGROUND: Head and neck cancer is the sixth most common cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most representative type. OSCC is a public health problem with high morbidity and poor survival rate. Epithelial-mesenchymal transition is emerging as a hallmark in OSCC. METHODS: In this study, we described the role of microRNAs in epithelial-mesenchymal transition regulation in OSCC based on a PubMed search using articles published in English between January 1, 2010, and January 31, 2018. RESULTS: MicroRNA's regulatory networks seem to be a hallmark of epithelial-mesenchymal transition in OSCC pathophysiology becoming a growing challenge to design new studies and strategies from biology to clinical applications. CONCLUSION: Therefore, we propose that targeting therapies to epithelial-mesenchymal transition-type cells, namely, coordinating microRNAs and/or hydrophobic drugs, such as conventional therapy, could be a promising strategy to improve the outcomes of patients with OSCC.
BACKGROUND: Head and neck cancer is the sixth most common cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most representative type. OSCC is a public health problem with high morbidity and poor survival rate. Epithelial-mesenchymal transition is emerging as a hallmark in OSCC. METHODS: In this study, we described the role of microRNAs in epithelial-mesenchymal transition regulation in OSCC based on a PubMed search using articles published in English between January 1, 2010, and January 31, 2018. RESULTS: MicroRNA's regulatory networks seem to be a hallmark of epithelial-mesenchymal transition in OSCC pathophysiology becoming a growing challenge to design new studies and strategies from biology to clinical applications. CONCLUSION: Therefore, we propose that targeting therapies to epithelial-mesenchymal transition-type cells, namely, coordinating microRNAs and/or hydrophobic drugs, such as conventional therapy, could be a promising strategy to improve the outcomes of patients with OSCC.
Authors: Chi Zhang; Hongfei Wang; Miao Deng; Lihong He; Fan Ping; Yuan He; Zhaona Fan; Bin Cheng; Juan Xia Journal: Int J Mol Med Date: 2021-02-04 Impact factor: 4.101