| Literature DB >> 30119957 |
Yi-Lei Fan1, Jian-Bing Wu2, Xing Ke2, Zhong-Ping Huang3.
Abstract
A series of oxime-functionalized nitrofuranylamides were designed, synthesized and evaluated for their in vitro anti-mycobacterial activities against MTB H37Rv and drug-resistant clinical isolates. Among them, two compounds 7a and 7b exhibited excellent activity against the three tested strains. Both of them were comparable to the first-line anti-TB agents INH and RIF against MTB H37Rv, and were far more potent than INH and RIF against MDR-TB 16833 and 16995 strains. Thus, both of them could act as leads for further optimization.Entities:
Keywords: Anti-mycobacterial; Anti-tubercular; Multi-drug resistant; Nitrofuran; Nitrofuranylamides; Oxime; Structure-activity relationship
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Year: 2018 PMID： 30119957 DOI： 10.1016/j.bmcl.2018.07.046
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823