Amalie Thorsti Møller Rønnstad1, Anne-Sofie Halling-Overgaard1, Carsten R Hamann1, Lone Skov1, Alexander Egeberg1, Jacob P Thyssen2. 1. Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Hellerup, Denmark; Copenhagen Research Group for Inflammatory Skin, Herlev and Gentofte Hospital, Hellerup, Denmark. 2. Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Hellerup, Denmark; Copenhagen Research Group for Inflammatory Skin, Herlev and Gentofte Hospital, Hellerup, Denmark; National Allergy Research Centre, Herlev and Gentofte Hospital, Hellerup, Denmark. Electronic address: jacob.p.thyssen@regionh.dk.
Abstract
BACKGROUND: Atopic dermatitis (AD) has been associated with anxiety and depression, but the magnitude of the alleged association is unknown. OBJECTIVE: To perform a systematic review and meta-analysis of the association between AD in children and adults and, respectively, depression, anxiety, and suicidal behavior. METHODS: The medical databases PubMed, Embase, and PsychINFO were searched. RESULTS: There was a significant association between adult AD and, respectively, depression (pooled odds ratio [OR], 2.19; 95% confidence interval [CI], 1.87-2.57) and anxiety (pooled OR, 2.19; 95% CI, 1.75-2.73). AD was also associated with depression in children (pooled OR, 1.27; 95% CI, 1.12-1.45); few data were available for anxiety. A positive association was found between AD in adults and adolescents and suicidal ideation (pooled OR, 4.32; 95% CI, 1.93-9.66). Only a few studies examined the risk of completed suicide, but the majority showed a positive association between completed suicide and AD. LIMITATIONS: Included studies used different definitions of depression and anxiety, and few studies examined the severity of AD. CONCLUSION: Depression, anxiety, and suicidal ideation should be considered by doctors when treating patients with AD. Because AD disease improvement appears to reduce these risks, this should be a priority.
BACKGROUND:Atopic dermatitis (AD) has been associated with anxiety and depression, but the magnitude of the alleged association is unknown. OBJECTIVE: To perform a systematic review and meta-analysis of the association between AD in children and adults and, respectively, depression, anxiety, and suicidal behavior. METHODS: The medical databases PubMed, Embase, and PsychINFO were searched. RESULTS: There was a significant association between adult AD and, respectively, depression (pooled odds ratio [OR], 2.19; 95% confidence interval [CI], 1.87-2.57) and anxiety (pooled OR, 2.19; 95% CI, 1.75-2.73). AD was also associated with depression in children (pooled OR, 1.27; 95% CI, 1.12-1.45); few data were available for anxiety. A positive association was found between AD in adults and adolescents and suicidal ideation (pooled OR, 4.32; 95% CI, 1.93-9.66). Only a few studies examined the risk of completed suicide, but the majority showed a positive association between completed suicide and AD. LIMITATIONS: Included studies used different definitions of depression and anxiety, and few studies examined the severity of AD. CONCLUSION:Depression, anxiety, and suicidal ideation should be considered by doctors when treating patients with AD. Because AD disease improvement appears to reduce these risks, this should be a priority.
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Authors: Jonathan I Silverberg; Jacob P Thyssen; Eric L Simpson; Gil Yosipovitch; Sonja Ständer; Hernan Valdez; Ricardo Rojo; Pinaki Biswas; Daniela E Myers; Claire Feeney; Marco DiBonaventura Journal: Am J Clin Dermatol Date: 2021-05-05 Impact factor: 7.403
Authors: Jonathan I Silverberg; Eric L Simpson; Jacob P Thyssen; Melinda Gooderham; Gary Chan; Claire Feeney; Pinaki Biswas; Hernan Valdez; Marco DiBonaventura; Chudy Nduaka; Ricardo Rojo Journal: JAMA Dermatol Date: 2020-08-01 Impact factor: 10.282