Literature DB >> 30119011

Pyrrole: An insight into recent pharmacological advances with structure activity relationship.

Shujauddin Ahmad1, Ozair Alam2, Mohd Javed Naim1, Mohammad Shaquiquzzaman1, M Mumtaz Alam1, Muzaffar Iqbal3.   

Abstract

Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for the generation of library of enormous lead molecules. Owing to its vast pharmacological profile, pyrrole and its analogues have drawn much attention of the researchers/chemists round the globe to be explored exhaustively for the benefit of mankind. This review focusses on recent advancements; pertaining to pyrrole scaffold, discussing various aspects of structure activity relationship and its bioactivities.
Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Anticancer; Antimicrobial; Pyrrole; Structure activity relationship

Mesh：

Substances：

Year:  2018        PMID： 30119011     DOI： 10.1016/j.ejmech.2018.08.002

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  23 in total

1.  Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives.

Authors:  Shu-Guang Zhang; Chao-Gen Liang; Yue-Qing Sun; Peng Teng; Jia-Qun Wang; Wei-Hua Zhang
Journal:  Mol Divers       Date:  2019-01-29       Impact factor: 2.943

2.  Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Acyclic α-N-Pyrrolyl/Indolyl Ketones.

Authors:  Remi Lavernhe; Eric J Alexy; Haiming Zhang; Brian M Stoltz
Journal:  Org Lett       Date:  2020-05-18       Impact factor: 6.005

3.  Insecticidal efficacy of six new pyrrole derivatives against four stored-product pests.

Authors:  Maria C Boukouvala; Nickolas G Kavallieratos; Christos G Athanassiou; Giovanni Benelli; Lazaros P Hadjiarapoglou
Journal:  Environ Sci Pollut Res Int       Date:  2019-08-13       Impact factor: 4.223

Review 4.  Synthesis of Biologically Active Molecules through Multicomponent Reactions.

Authors:  Daniel Insuasty; Juan Castillo; Diana Becerra; Hugo Rojas; Rodrigo Abonia
Journal:  Molecules       Date:  2020-01-24       Impact factor: 4.411

Review 5.  Isocyanide-Based Multicomponent Reactions in Water: Advanced Green Tools for the Synthesis of Heterocyclic Compounds.

Authors:  Siamak Javanbakht; Mohammad Taghi Nazeri; Hassan Farhid; Tahereh Nasiriani; Vida Khodkari; Ahmad Shaabani
Journal:  Top Curr Chem (Cham)       Date:  2022-09-22

Review 6.  Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018-2021).

Authors:  Ashima Dhiman; Rupam Sharma; Rajesh K Singh
Journal:  Acta Pharm Sin B       Date:  2022-04-01       Impact factor: 14.903

7.  Structural Rigidification of N-Aryl-pyrroles into Indoles Active against Intracellular and Drug-Resistant Mycobacteria.

Authors:  Dorothy Semenya; Meir Touitou; Camila Maringolo Ribeiro; Fernando Rogerio Pavan; Luca Pisano; Vinayak Singh; Kelly Chibale; Georg Bano; Anita Toscani; Fabrizio Manetti; Beatrice Gianibbi; Daniele Castagnolo
Journal:  ACS Med Chem Lett       Date:  2021-12-08       Impact factor: 4.345

8.  Synthesis of Pyrroles via Consecutive 6π-Electrocyclization/Ring-Contraction of Sulfilimines.

Authors:  Franz-Lucas Haut; Niklas J Feichtinger; Immanuel Plangger; Lukas A Wein; Mira Müller; Tim-Niclas Streit; Klaus Wurst; Maren Podewitz; Thomas Magauer
Journal:  J Am Chem Soc       Date:  2021-06-09       Impact factor: 15.419

Review 9.  Recent Strides in the Transition Metal-Free Cross-Coupling of Haloacetylenes with Electron-Rich Heterocycles in Solid Media.

Authors:  Lyubov' N Sobenina; Boris A Trofimov
Journal:  Molecules       Date:  2020-05-27       Impact factor: 4.411

10.  Synthesis of 1-(5-Chloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives and Their Antioxidant Activity.

Authors:  Ingrida Tumosienė; Kristina Kantminienė; Ilona Jonuškienė; Artūras Peleckis; Sergey Belyakov; Vytautas Mickevičius
Journal:  Molecules       Date:  2019-03-09       Impact factor: 4.411
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