Ling-Bing Meng1, Ze-Mou Yu2, Peng Guo3, Qing-Qing Wang4, Ruo-Mei Qi5, Meng-Jie Shan6, Jian Lv7, Tao Gong8. 1. Neurology Department, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR China. 2. Department of Neurology, Peking University First Hospital, Beijing, PR China. 3. Department of Orthopedics, The Fourth Hospital of Hebei Medical University, PR China. 4. Department of Medical Oncology, Hebei Medical University, PR China. 5. The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR China. 6. MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China. 7. Second Department of Surgery, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei 050011, PR China. 8. Neurology Department, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR China. Electronic address: mac0852@163.com.
Abstract
INTRODUCTION: Cardiac-cerebral vascular diseases (CCVDs) are global health problems due to the characteristic of high mortality. It is found that atherosclerosis (AS), a main cause of CCVDs, is significantly relevant to the change of intimal and media thickness. Neutrophil count (NEU) and neutrophil-lymphocyte ratio (N/L) are recognized possible risk factors for atherosclerosis (AS). However, there are few studies on the separate relationship between carotid intimal thickness, media thickness and NEU, N/L. This study explored the respective effects of NEU and N/L on AS and intimal, media thickness. MATERIALS AND METHODS: The χ2, Spearman's rho test, and multiple linear regression were implemented to analyze the relevance between blood parameters and intimal-media thickness. The potential factors, affecting non-depression time (NDT), is identified by univariate Cox regression. ROC curve was performed to determine the ability of blood parameters to predict intimal-media thickness. Immunohistochemistry was implemented. RESULTS AND CONCLUSION: Based on χ2, Spearman's rho test and multiple linear regression, NEU is related with intimal thickness (P < 0.05). Furthermore, NEU can predict the intimal thickness through the ROC curve. What's more, N/L is a risk factor of carotid media thickness (P < 0.05) by the Spearman's rho test, and is also correlated with poor NDT (P < 0.05) based on univariate Cox proportional regression analysis. Through ROC curve, N/L can predict the carotid media thickness. The carotid atherosclerotic endarterium is richest in macrophagocytes, and the arrangement of endotheliocytes is disordered. In summary, the increased NEU and N/L respectively have a strong correlation and precise predictability for carotid intimal and media thickness of atherosclerosis.
INTRODUCTION:Cardiac-cerebral vascular diseases (CCVDs) are global health problems due to the characteristic of high mortality. It is found that atherosclerosis (AS), a main cause of CCVDs, is significantly relevant to the change of intimal and media thickness. Neutrophil count (NEU) and neutrophil-lymphocyte ratio (N/L) are recognized possible risk factors for atherosclerosis (AS). However, there are few studies on the separate relationship between carotid intimal thickness, media thickness and NEU, N/L. This study explored the respective effects of NEU and N/L on AS and intimal, media thickness. MATERIALS AND METHODS: The χ2, Spearman's rho test, and multiple linear regression were implemented to analyze the relevance between blood parameters and intimal-media thickness. The potential factors, affecting non-depression time (NDT), is identified by univariate Cox regression. ROC curve was performed to determine the ability of blood parameters to predict intimal-media thickness. Immunohistochemistry was implemented. RESULTS AND CONCLUSION: Based on χ2, Spearman's rho test and multiple linear regression, NEU is related with intimal thickness (P < 0.05). Furthermore, NEU can predict the intimal thickness through the ROC curve. What's more, N/L is a risk factor of carotid media thickness (P < 0.05) by the Spearman's rho test, and is also correlated with poor NDT (P < 0.05) based on univariate Cox proportional regression analysis. Through ROC curve, N/L can predict the carotid media thickness. The carotid atherosclerotic endarterium is richest in macrophagocytes, and the arrangement of endotheliocytes is disordered. In summary, the increased NEU and N/L respectively have a strong correlation and precise predictability for carotid intimal and media thickness of atherosclerosis.
Authors: Clara Ballerini; Alfred K Njamnshi; Sharon L Juliano; Rajesh N Kalaria; Roberto Furlan; Rufus O Akinyemi Journal: Front Immunol Date: 2022-06-13 Impact factor: 8.786
Authors: Ernst Mayerhofer; Franz Ratzinger; Nina Elvira Kienreich; Annika Stiel; Nadine Witzeneder; Eva Schrefl; Georg Greiner; Christoph Wegscheider; Irene Graf; Klaus Schmetterer; Rodrig Marculescu; Thomas Szekeres; Thomas Perkmann; Martina Fondi; Oswald Wagner; Harald Esterbauer; Matthias Mayerhofer; Stefana Holocher-Ertl; Claudia Wojnarowski; Gregor Hoermann Journal: Front Pediatr Date: 2020-02-21 Impact factor: 3.418