Enrico Borrelli1, Yue Shi2, Akihito Uji2, Siva Balasubramanian2, Marco Nassisi2, David Sarraf3, SriniVas R Sadda4. 1. Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, Italy. 2. Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. 3. Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Greater Los Angeles VA Healthcare Center, Los Angeles, California, USA. 4. Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. Electronic address: SSadda@doheny.org.
Abstract
PURPOSE: To quantitate regional differences in the choriocapillaris (CC) of patients with intermediate age-related macular degeneration (iAMD), using swept-source optical coherence tomography angiography (SS-OCTA) imaging. DESIGN: Cross-sectional study. METHODS: Subjects were imaged with the SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc, Dublin, California, USA). The CC en face images were first compensated for the signal attenuation caused by drusen by using the structural information from the same slab. Subsequently, for each eye, 2 compensated CC en face images generated from 2 different OCTA volume scan sets were registered and averaged. The averaged CC images were then exported to ImageJ and binarized for subsequent quantitative analysis. In addition to the analysis of the whole averaged CC en face image in iAMD eyes, quantitative analysis was also performed in 3 different regions: (1) drusen region, (2) 150-μm-wide ring around the drusen border, and (3) drusen-free region. RESULTS: Thirty eyes (30 patients) with iAMD and 30 healthy eyes from 30 controls were enrolled. Compared with controls, iAMD eyes displayed a lower number of signal voids (median and interquartile range [IQR]: 2561 and 2343-2746 vs 2734 and 2558-2834; P = .013), a greater signal void average size (median, IQR: 581.9 μm2, 466.1-726.9 μm2 vs 503.8 μm2, 429.1-576.8 μm2; P = .027), and a greater total signal void area (median, IQR: 26.0%, 22.1%-29.6% vs 23.8%, 21.2%-26.4%; P = .038). In multiple regression analysis, the presence of iAMD was not significantly associated with any of the CC variables. By contrast, the drusen region area was significantly associated with CC alterations. In the evaluation of the iAMD group, both the area underneath drusen and the 150-μm-wide ring region around drusen were characterized by an increased total signal void area (P = .005 and P = .045, respectively) vs the drusen-free region. CONCLUSIONS: Intermediate AMD eyes demonstrated increased CC flow impairment, which co-localizes to the area of CC beneath and immediately surrounding drusen.
PURPOSE: To quantitate regional differences in the choriocapillaris (CC) of patients with intermediate age-related macular degeneration (iAMD), using swept-source optical coherence tomography angiography (SS-OCTA) imaging. DESIGN: Cross-sectional study. METHODS: Subjects were imaged with the SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc, Dublin, California, USA). The CC en face images were first compensated for the signal attenuation caused by drusen by using the structural information from the same slab. Subsequently, for each eye, 2 compensated CC en face images generated from 2 different OCTA volume scan sets were registered and averaged. The averaged CC images were then exported to ImageJ and binarized for subsequent quantitative analysis. In addition to the analysis of the whole averaged CC en face image in iAMD eyes, quantitative analysis was also performed in 3 different regions: (1) drusen region, (2) 150-μm-wide ring around the drusen border, and (3) drusen-free region. RESULTS: Thirty eyes (30 patients) with iAMD and 30 healthy eyes from 30 controls were enrolled. Compared with controls, iAMD eyes displayed a lower number of signal voids (median and interquartile range [IQR]: 2561 and 2343-2746 vs 2734 and 2558-2834; P = .013), a greater signal void average size (median, IQR: 581.9 μm2, 466.1-726.9 μm2 vs 503.8 μm2, 429.1-576.8 μm2; P = .027), and a greater total signal void area (median, IQR: 26.0%, 22.1%-29.6% vs 23.8%, 21.2%-26.4%; P = .038). In multiple regression analysis, the presence of iAMD was not significantly associated with any of the CC variables. By contrast, the drusen region area was significantly associated with CC alterations. In the evaluation of the iAMD group, both the area underneath drusen and the 150-μm-wide ring region around drusen were characterized by an increased total signal void area (P = .005 and P = .045, respectively) vs the drusen-free region. CONCLUSIONS: Intermediate AMD eyes demonstrated increased CC flow impairment, which co-localizes to the area of CC beneath and immediately surrounding drusen.
Authors: Jin Yang; Qinqin Zhang; Elie H Motulsky; Marie Thulliez; Yingying Shi; Cancan Lyu; Luis de Sisternes; Mary K Durbin; William Feuer; Ruikang K Wang; Giovanni Gregori; Philip J Rosenfeld Journal: Am J Ophthalmol Date: 2019-06-21 Impact factor: 5.258
Authors: Yingying Shi; Qinqin Zhang; Fang Zheng; Jonathan F Russell; Elie H Motulsky; James T Banta; Zhongdi Chu; Hao Zhou; Nimesh A Patel; Luis de Sisternes; Mary K Durbin; William Feuer; Giovanni Gregori; Ruikang K Wang; Philip J Rosenfeld Journal: Am J Ophthalmol Date: 2019-09-25 Impact factor: 5.258
Authors: Julia Schottenhamml; Eric M Moult; Stefan B Ploner; Siyu Chen; Eduardo Novais; Lennart Husvogt; Jay S Duker; Nadia K Waheed; James G Fujimoto; Andreas K Maier Journal: Biomed Opt Express Date: 2020-12-08 Impact factor: 3.732
Authors: Yingying Shi; Zhongdi Chu; Liang Wang; Qinqin Zhang; William Feuer; Luis de Sisternes; Mary K Durbin; Giovanni Gregori; Ruikang K Wang; Philip J Rosenfeld Journal: Am J Ophthalmol Date: 2020-07-02 Impact factor: 5.258
Authors: Sophie C Lee; Steven Tran; Aana Amin; Lawrence S Morse; Ala Moshiri; Susanna S Park; Glenn Yiu Journal: Am J Ophthalmol Date: 2019-12-16 Impact factor: 5.258