Literature DB >> 3011826

Platelet-derived growth factor: mechanism of action and relation to oncogenes.

C H Heldin, C Betsholtz, A Johnsson, M Nistér, B Ek, L Rönnstrand, A Wasteson, B Westermark.   

Abstract

Recent studies of platelet-derived growth factor (PDGF) have revealed several structural and functional similarities between this growth factor or components linked to its mechanism of action and certain oncogene products: PDGF itself has a structural homology with the transforming protein of simian sarcoma virus, the PDGF receptor has a functional homology (tyrosine kinase activity) with a family of oncogene products, and PDGF induces the expression of the cellular counterparts of myc and fos. In addition, several tumour cell lines have been found to produce PDGF-like growth factors, which may cause autocrine stimulation of growth. We interpret these findings as indicating that regulatory components along the PDGF-dependent mitogenic pathway may have oncogenic properties if they are inappropriately expressed or activated.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3011826     DOI： 10.1242/jcs.1985.supplement_3.7

Source DB:  PubMed          Journal:  J Cell Sci Suppl        ISSN： 0269-3518


  7 in total

Review 1.  Oncogenes and their role in human neoplasia.

Authors:  D N Singh
Journal:  Indian J Pediatr       Date:  1987 Nov-Dec       Impact factor: 1.967

2.  Transforming growth factor beta 1-hyaluronic acid interaction.

Authors:  P Locci; L Marinucci; C Lilli; D Martinese; E Becchetti
Journal:  Cell Tissue Res       Date:  1995-08       Impact factor: 5.249

3.  PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

Authors:  Vashe Chandrakanthan; Avani Yeola; Jair C Kwan; Rema A Oliver; Qiao Qiao; Young Chan Kang; Peter Zarzour; Dominik Beck; Lies Boelen; Ashwin Unnikrishnan; Jeanette E Villanueva; Andrea C Nunez; Kathy Knezevic; Cintia Palu; Rabab Nasrallah; Michael Carnell; Alex Macmillan; Renee Whan; Yan Yu; Philip Hardy; Shane T Grey; Amadeus Gladbach; Fabien Delerue; Lars Ittner; Ralph Mobbs; Carl R Walkley; Louise E Purton; Robyn L Ward; Jason W H Wong; Luke B Hesson; William Walsh; John E Pimanda
Journal:  Proc Natl Acad Sci U S A       Date:  2016-04-04       Impact factor: 11.205

4.  Polarized secretion of a platelet-derived growth factor-like chemotactic factor by endothelial cells in vitro.

Authors:  H G Zerwes; W Risau
Journal:  J Cell Biol       Date:  1987-11       Impact factor: 10.539

5.  Dual roles of endothelial FGF-2-FGFR1-PDGF-BB and perivascular FGF-2-FGFR2-PDGFRβ signaling pathways in tumor vascular remodeling.

Authors:  Kayoko Hosaka; Yunlong Yang; Masaki Nakamura; Patrik Andersson; Xiaojuan Yang; Yin Zhang; Takahiro Seki; Martin Scherzer; Olivier Dubey; Xinsheng Wang; Yihai Cao
Journal:  Cell Discov       Date:  2018-01-16       Impact factor: 10.849

Review 6.  The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues.

Authors:  Eric S Goetzman; Edward V Prochownik
Journal:  Front Endocrinol (Lausanne)       Date:  2018-04-12       Impact factor: 5.555

7.  The Role of Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Predicting Neoadjuvant Chemotherapy Response in Breast Cancer.

Authors:  Hee Yeon Kim; Tae Hyun Kim; Hye Kyoung Yoon; Anbok Lee
Journal:  J Breast Cancer       Date:  2019-09-18       Impact factor: 3.588
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.