Literature DB >> 301177

Histocompatibility linked immune responsiveness and restrictions imposed on sensitized lymphocytes.

J F Miller, M A Vadas, A Whitelaw, J Gamble, C Bernard.   

Abstract

Delayed-type hypersensitivity (DTH) transfer to GAT was restricted by the I-A region of the major histocompatibility complex (MHC). Sensitized cells from F1 hybrid mice between responder and nonresponder strains transferred DTH to syngeneic F1 mice and to naive parental strain recipients of the responder but not of the nonresponder haplotypes. These results are interpreted to favor the postulate that the MHC-linked Ir genes exert their effects by coding for components which allow interactions between particular I region gene products and the region to form stable structures immunogenic for DTH T cells.

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Year:  1977        PMID： 301177      PMCID： PMC2180690          DOI： 10.1084/jem.145.6.1623

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

1.  T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera.

Authors:  R H Schwartz; C S David; D H Sachs; W E Paul
Journal:  J Immunol       Date:  1976-08       Impact factor: 5.422

2.  Helper T cells recognise antigen and macrophage surface components simultaneously.

Authors:  J W Kappler; P C Marrack
Journal:  Nature       Date:  1976-08-26       Impact factor: 49.962

3.  Role of major histocompatibility complex gene products in delayed-type hypersensitivity.

Authors:  J F Miller; M A Vadas; A Whitelaw; J Gamble
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

Review 4.  Functional specificity of thymus- dependent lymphocytes.

Authors:  W E Paul; B Benacerraf
Journal:  Science       Date:  1977-03-25       Impact factor: 47.728

5.  Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.

Authors:  P C Doherty; R V Blanden; R M Zinkernagel
Journal:  Transplant Rev       Date:  1976

6.  A radioisotopic method to measure delayed type hypersensitivity in the mouse. I. Studies in sensitized and normal mice.

Authors:  M A Vadas; J F Miller; J Gamble; A Whitelaw
Journal:  Int Arch Allergy Appl Immunol       Date:  1975

7.  Determinants of antigenic molecules responsible for genetically controlled regulation of immune responses.

Authors:  M Schwartz; C Waltenbaugh; M Dorf; R Cesla; M Sela; B Benacerraf
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205

8.  Multiple H-2 linked immune response gene control of H-2 D-associated T-cell-mediated lympholysis to trinitrophenyl-modified autologous cells: Ir-like genes mapping to the left of I-A and within the I region.

Authors:  A M Schmitt-Verhulst; G M Shearer
Journal:  J Exp Med       Date:  1976-12-01       Impact factor: 14.307

9.  The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.

Authors:  P Erb; M Feldmann
Journal:  J Exp Med       Date:  1975-08-01       Impact factor: 14.307

10.  Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT).

Authors:  J A Kapp; C W Pierce; S Schlossman; B Benacerraf
Journal:  J Exp Med       Date:  1974-09-01       Impact factor: 14.307
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  12 in total

1.  Mechanisms of genetic control of immune responses. II. Nonresponsiveness in BALB/c GT-specific cell-mediated immune responses does not correlate with the absence of functional T cells or the induction of suppressor T cells.

Authors:  M K Kennedy; M K Jenkins; S D Miller
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

Review 2.  Antigen specific T cell factors.

Authors:  M Feldmann; S Kontiainen
Journal:  Mol Cell Biochem       Date:  1980-05-07       Impact factor: 3.396

3.  H-2-linked genes which modify resistance of C57BL/10 mice to subcutaneous infection with Mycobacterium lepraemurium.

Authors:  J Curtis; H Akuffo-Adu; J L Turk
Journal:  Infect Immun       Date:  1984-12       Impact factor: 3.441

4.  The role of macrophages in the lymphoproliferative response to Mycobacterium leprae in vitro.

Authors:  H Hirschberg
Journal:  Clin Exp Immunol       Date:  1978-10       Impact factor: 4.330

5.  Genetic regulation of delayed-type hypersensitivity responses to poly (Tyr,Glu)-poly(DLAla)--poly(Lys): expression of the genetic defect in the induction and manifestation phases in H-2s and H-2f mice.

Authors:  G Strassman; E Mozes; Z Eshhar
Journal:  Immunology       Date:  1982-03       Impact factor: 7.397

6.  Mechanisms of genetic control of immune responses. I. Evidence for distinct multi-step helper T-cell pathways in cellular and humoral responses to GAT.

Authors:  S D Miller; R W Melvold; C Waltenbaugh
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

7.  Cytotoxic T-cell responses to H-Y: mapping of the Ir genes.

Authors:  M Hurme; C M Hetherington; P R Chandler; E Simpson
Journal:  J Exp Med       Date:  1978-03-01       Impact factor: 14.307

8.  Genetic regulation of delayed-type hypersensitivity responses to poly(LTyr,LGlu)-poly(DLAla)--poly(LLys). II. Evidence for a T-T-cell collaboration in delayed-type hypersensitivity responses and for a T-cell defect at the efferent phase in nonresponder H-2k mice.

Authors:  G Strassmann; Z Eshhar; E Mozes
Journal:  J Exp Med       Date:  1980-03-01       Impact factor: 14.307

9.  Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages.

Authors:  C W Pierce; R N Germain; J A Kapp; B Benacerraf
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307

10.  Genetic regulation of delayed-type hypersensitivity responses to poly(LTyr,LGu)-poly(DLAla)--poly(LLys). I. Expression of the genetic defect at two phases of the immune process.

Authors:  G Strassmann; Z Eshhar; E Mozes
Journal:  J Exp Med       Date:  1980-02-01       Impact factor: 14.307
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