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Literature DB >> 30117620

α-Sila-Dipeptides: Synthesis and Characterization.

Boris Minkovich¹, Ilya Ruderfer¹, Alexander Kaushansky¹, Dmitry Bravo-Zhivotovskii¹, Yitzhak Apeloig¹.

Abstract

The first two α-sila-dipeptides, 7 and cyclo-sila-dipeptide 8, were synthesized and characterized by several methods, including X-ray crystallography. Bulky t-BuMe2 Si substituents provide some kinetic stabilization to the synthesized molecules. 7 and 8 are the first examples of a "Si for C switch" in the central α-position of an amino acid or a peptide, in which silicon is bonded to both the amino and the carbonyl groups.

Entities: Chemical

Keywords: Si for C switch; peptidomimetics; sila-piperazine; α-sila-dipeptides

Mesh：

Substances：
Dipeptides
Silicon

Year: 2018 PMID： 30117620 DOI： 10.1002/anie.201807027

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

2 in total

1. Fe^II-catalysed insertion reaction of α-diazocarbonyls into X-H bonds (X = Si, S, N, and O) in dimethyl carbonate as a suitable solvent alternative.

Authors: Nour Tanbouza; Hoda Keipour; Thierry Ollevier
Journal: RSC Adv Date: 2019-10-02 Impact factor: 4.036

2. On the Potential of Silicon as a Building Block for Life.

Authors: Janusz Jurand Petkowski; William Bains; Sara Seager
Journal: Life (Basel) Date: 2020-06-10

2 in total

α-Sila-Dipeptides: Synthesis and Characterization.

1. FeII-catalysed insertion reaction of α-diazocarbonyls into X-H bonds (X = Si, S, N, and O) in dimethyl carbonate as a suitable solvent alternative.

2. On the Potential of Silicon as a Building Block for Life.

1. Fe^II-catalysed insertion reaction of α-diazocarbonyls into X-H bonds (X = Si, S, N, and O) in dimethyl carbonate as a suitable solvent alternative.