| Literature DB >> 3011648 |
T Lund, A H Geurts van Kessel, S Haun, J E Dixon.
Abstract
The polypeptide hormones gastrin and cholecystokinin are structurally related, having the identical pentapeptide GWMDF located at their C-terminus. The precursors to these two hormones also show amino acid homology, suggesting that they may have a common ancestral origin. Recombinant DNA clones corresponding to gene fragments encoding human gastrin and cholecystokinin were used to determine their respective chromosomal localization by analyzing human-rodent cell lines. We have assigned the cholecystokinin gene to human chromosome 3q12-3pter and the gastrin gene to chromosome 17q.Entities:
Mesh:
Substances:
Year: 1986 PMID: 3011648 DOI: 10.1007/bf00292669
Source DB: PubMed Journal: Hum Genet ISSN: 0340-6717 Impact factor: 4.132