Literature DB >> 3011602

Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens.

M Emi, Y Nakamura, M Ogawa, T Yamamoto, T Nishide, T Mori, K Matsubara.   

Abstract

Two cDNA clones encoding two major human trypsinogen isozymes were isolated from a human pancreatic cDNA library. The deduced amino acid (aa) sequences of the two trypsinogen precursors are found to have 89% sequence homology, and have the same number of aa (247), including 15 aa for a signal peptide and 8 aa for an activation peptide. Southern blot analysis of human genomic DNA using the cloned cDNA as a probe, revealed that the human trypsinogen genes constitute a multigene family of more than ten genes.

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Year:  1986        PMID： 3011602     DOI： 10.1016/0378-1119(86)90111-3

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  28 in total

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Authors:  A Paju; A Bjartell; W M Zhang; S Nordling; A Borgström; J Hansson; U H Stenman
Journal:  Am J Pathol       Date:  2000-12       Impact factor: 4.307

Review 2.  Human pancreatic digestive enzymes.

Authors:  David C Whitcomb; Mark E Lowe
Journal:  Dig Dis Sci       Date:  2007-01-05       Impact factor: 3.199

Review 3.  Invertebrate trypsins: a review.

Authors:  Adriana Muhlia-Almazán; Arturo Sánchez-Paz; Fernando L García-Carreño
Journal:  J Comp Physiol B       Date:  2008-04-11       Impact factor: 2.200

4.  Automatic generation of primary sequence patterns from sets of related protein sequences.

Authors:  R F Smith; T F Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

5.  Mutations in exons 2 and 3 of the cationic trypsinogen gene in Japanese families with hereditary pancreatitis.

Authors:  I Nishimori; M Kamakura; K Fujikawa-Adachi; M Morita; S Onishi; K Yokoyama; I Makino; H Ishida; M Yamamoto; S Watanabe; M Ogawa
Journal:  Gut       Date:  1999-02       Impact factor: 23.059

6.  A trypsin homolog in amphioxus: expression, enzymatic activity and evolution.

Authors:  Wenrong Feng; Shicui Zhang
Journal:  Mol Biol Rep       Date:  2011-05-29       Impact factor: 2.316

7.  Stimulation of cellular growth and adhesion to fibronectin and vitronectin in culture and tumorigenicity in nude mice by overexpression of trypsinogen in human gastric cancer cells.

Authors:  S Miyata; Y Miyagi; N Koshikawa; Y Nagashima; Y Kato; H Yasumitsu; F Hirahara; K Misugi; K Miyazaki
Journal:  Clin Exp Metastasis       Date:  1998-10       Impact factor: 5.150

8.  A new polymorphism for the RI22H mutation in hereditary pancreatitis.

Authors:  N Howes; W Greenhalf; S Rutherford; M O'Donnell; R Mountford; I Ellis; D Whitcomb; C Imrie; B Drumm; J P Neoptolemos
Journal:  Gut       Date:  2001-02       Impact factor: 23.059

9.  Nucleotide sequence of the human pancreatic trypsinogen III cDNA.

Authors:  T Tani; I Kawashima; K Mita; Y Takiguchi
Journal:  Nucleic Acids Res       Date:  1990-03-25       Impact factor: 16.971

10.  Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.

Authors:  Itay Cohen; Olumide Kayode; Alexandra Hockla; Banumathi Sankaran; Derek C Radisky; Evette S Radisky; Niv Papo
Journal:  Biochem J       Date:  2016-03-08       Impact factor: 3.857
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