Literature DB >> 3011509

Mechanism of glucagon stimulation of fructose-1,6-bisphosphatase in rat hepatocytes. Involvement of a low-Mr activator.

E Casteleijn, H C van Rooij, T J van Berkel, J F Koster.   

Abstract

Isolated rat hepatocytes were incubated in the absence or presence of glucagon and the activity of fructose-1,6-bisphosphatase was measured in cell extracts. After glucagon treatment the Vmax was increased (20-50%) whereas the Km remained unchanged. The stimulation was complete at 5 min after addition of glucagon. The glucagon concentration needed for maximal stimulation was 10(-9) M. After gel filtration the fructose-1,6-bisphosphatase activity in extracts of glucagon-treated cells was lowered to the control level. The effect of glucagon could not be completely mimicked by dibutyryl cAMP. The data indicate that in addition to the possible regulatory role of enzyme phosphorylation, a positive effector is involved in the stimulation of fructose-1,6-bisphosphatase activity by glucagon.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3011509     DOI： 10.1016/0014-5793(86)80607-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Cellular communication inside the liver. Binding, conversion and metabolic effect of prostaglandin D2 on parenchymal liver cells.

Authors:  J Kuiper; F J Zijlstra; J A Kamps; T J Van Berkel
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

2.  Recognition of chylomicron remnants and beta-migrating very-low-density lipoproteins by the remnant receptor of parenchymal liver cells is distinct from the liver alpha 2-macroglobulin-recognition site.

Authors:  M C van Dijk; G J Ziere; W Boers; C Linthorst; M K Bijsterbosch; T J van Berkel
Journal:  Biochem J       Date:  1991-11-01       Impact factor: 3.857

3.  Massive targeting of liposomes, surface-modified with anionized albumins, to hepatic endothelial cells.

Authors:  J A Kamps; H W Morselt; P J Swart; D K Meijer; G L Scherphof
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

4.  Conditioned media of Kupffer and endothelial liver cells influence protein phosphorylation in parenchymal liver cells. Involvement of prostaglandins.

Authors:  E Casteleijn; J Kuiper; H C Van Rooij; J F Koster; T J Van Berkel
Journal:  Biochem J       Date:  1988-06-01       Impact factor: 3.857

5.  Characterization of a receptor for oxidized low-density lipoproteins on rat Kupffer cells: similarity to macrosialin.

Authors:  A G Van Velzen; R P Da Silva; S Gordon; T J Van Berkel
Journal:  Biochem J       Date:  1997-03-01       Impact factor: 3.857

Review 6.  Glucagon, cyclic AMP, and hepatic glucose mobilization: A half-century of uncertainty.

Authors:  Robert L Rodgers
Journal:  Physiol Rep       Date:  2022-05

7.  Characterization of the interaction of galactose-exposing particles with rat Kupffer cells.

Authors:  J Kuiper; H F Bakkeren; E A Biessen; T J Van Berkel
Journal:  Biochem J       Date:  1994-04-01       Impact factor: 3.857

8.  Role of the scavenger receptor in the uptake of methylamine-activated alpha 2-macroglobulin by rat liver.

Authors:  M C van Dijk; W Boers; C Linthorst; T J van Berkel
Journal:  Biochem J       Date:  1992-10-15       Impact factor: 3.857

9.  Prostaglandin D2 mediates the stimulation of glycogenolysis in the liver by phorbol ester.

Authors:  E Casteleijn; J Kuiper; H C Van Rooij; J A Kamps; J F Koster; T J Van Berkel
Journal:  Biochem J       Date:  1988-02-15       Impact factor: 3.857

10.  Interaction of mutants of tissue-type plasminogen activator with liver cells: effect of domain deletions.

Authors:  J Kuiper; A Van't Hof; M Otter; E A Biessen; D C Rijken; T J van Berkel
Journal:  Biochem J       Date:  1996-02-01       Impact factor: 3.857
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.