Literature DB >> 3011507

Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium.

S Marc, D Leiber, S Harbon.   

Abstract

In the guinea pig myometrium prelabelled with myo-[2-3H]inositol, carbachol and oxytocin enhanced a concentration-dependent and rapid release of IP3 which preceded that of IP2 and IP1. The specific receptor-mediated phospholipase C activation degrading PIP2 to IP3 did not require the presence of extracellular Ca2+. The ionophore A23187 as well as K+ depolarization failed to increase inositol phosphate accumulation. It is proposed that IP3 could have a role in the contraction of uterine smooth muscle elicited by the activation of muscarinic as well as of oxytocin receptors.

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Year:  1986        PMID： 3011507     DOI： 10.1016/0014-5793(86)80561-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

1.  Identification and function of ryanodine receptor subtype 3 in non-pregnant mouse myometrial cells.

Authors:  J Mironneau; N Macrez; J L Morel; V Sorrentino; C Mironneau
Journal:  J Physiol       Date:  2002-02-01       Impact factor: 5.182

2.  AlF-4 inhibits the accumulation of Ca in the endoplasmic reticulum in intact myometrial strips, but not in the rabbit ear artery.

Authors:  L Missiaen; Y Kanmura; F Wuytack; L Raeymaekers; I Declerck; G Droogmans; R Casteels
Journal:  Pflugers Arch       Date:  1989-08       Impact factor: 3.657

3.  Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets.

Authors:  Z Y Gao; G Drews; J C Henquin
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

4.  Properties of voltage-activated [Ca2+]i transients in single smooth muscle cells isolated from pregnant rat uterus.

Authors:  A V Shmigol; D A Eisner; S Wray
Journal:  J Physiol       Date:  1998-09-15       Impact factor: 5.182

5.  Intra-and intercellular calcium waves in cultured human myometrium.

Authors:  R C Young; R O Hession
Journal:  J Muscle Res Cell Motil       Date:  1996-06       Impact factor: 2.698

6.  Oxytocin receptor couples to the 80 kDa Gh alpha family protein in human myometrium.

Authors:  K J Baek; N S Kwon; H S Lee; M S Kim; P Muralidhar; M J Im
Journal:  Biochem J       Date:  1996-05-01       Impact factor: 3.857

7.  Alpha 2-adrenoceptors activate dihydropyridine-sensitive calcium channels via Gi-proteins and protein kinase C in rat portal vein myocytes.

Authors:  N Leprêtre; J Mironneau
Journal:  Pflugers Arch       Date:  1994-12       Impact factor: 3.657

8.  Oxytocin mobilizes calcium from a unique heparin-sensitive and thapsigargin-sensitive store in single myometrial cells from pregnant rats.

Authors:  S Arnaudeau; N Leprêtre; J Mironneau
Journal:  Pflugers Arch       Date:  1994-08       Impact factor: 3.657

9.  Novel pharmacological profile of muscarinic receptors mediating contraction of the guinea-pig uterus.

Authors:  F Dörje; T Friebe; R Tacke; E Mutschler; G Lambrecht
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-09       Impact factor: 3.000

10.  Gestational changes in the utilization of intracellularly stored calcium in the myometrium of guinea-pigs.

Authors:  H A Coleman; P G McShane; H C Parkington
Journal:  J Physiol       Date:  1988-05       Impact factor: 5.182
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