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Literature DB >> 301146

Alpha-1-antitrypsin globules in the liver and PiM phenotype.

Abstract

The finding is recorded of typical a1-antitrypsin globules, confirmed by immunofluorescence and immunoperoxidase methods, in the hepatocytes of a patient shown to have a normal serum antitrypsin level and normal phenotype (TiM) for a1-antitrypsin. The identification of such globules can no longer be regarded as conclusive evidence of an abnormal a1-antitrypsin phenotype.

Entities: Gene Species

Mesh：

Substances：
alpha 1-Antitrypsin

Year: 1977 PMID： 301146 PMCID： PMC476441 DOI： 10.1136/jcp.30.5.464

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

9 in total

1. The ultrastructure of hepatocytes in alpha-1-antitrypsin deficiency with the genotype Pi--.

Authors: G Feldmann; J P Martin; R Sesboue; C Ropartz; R Perelman; M Nathanson; P Seringe; J P Benhamou
Journal: Gut Date: 1975-10 Impact factor: 23.059

2. Genetic aspects of the Pi system.

Authors: P J Cook
Journal: Postgrad Med J Date: 1974-06 Impact factor: 2.401

3. Alpha 1 antitrypsinin the livers of patients with emphysema.

Authors: J Lieberman; C Mittman; H W Gordon
Journal: Science Date: 1972-01-07 Impact factor: 47.728

4. The genetics of alpha1-antitrypsin: a family study in England and Scotland.

Authors: P J Cook
Journal: Ann Hum Genet Date: 1975-01 Impact factor: 1.670

5. Letter: Alpha1-antitrypsin deficiency.

Authors: J P Martin; R Charlionet; R Sesboüe; C Ropartz
Journal: Lancet Date: 1976-02-21 Impact factor: 79.321

6. Liver, lung and malignant disease in heterozygous (Pi MZ) alpha1-antitrypsin deficiency.

Authors: S Eriksson; T Moestrup; I Hägerstrand
Journal: Acta Med Scand Date: 1975-10

7. Alpha-1-antitrypsin bodies in the liver.

Authors: W K Blenkinsopp; G P Haffenden
Journal: J Clin Pathol Date: 1977-02 Impact factor: 3.411

Review 8. The current status of alpha-1-antityrpsin, a protease inhibitor, in gastrointestinal disease.

Authors: H L Sharp
Journal: Gastroenterology Date: 1976-04 Impact factor: 22.682

9. Alpha 1 -antitrypsin (A1AT) accumulation in livers of emphysematous patients with A1AT deficiency.

Authors: H W Gordon; J Dixon; J C Rogers; C Mittman; J Lieberman
Journal: Hum Pathol Date: 1972-09 Impact factor: 3.466

9 in total

8 in total

Alpha-1-antitrypsin globules in the liver and PiM phenotype.

1. The ultrastructure of hepatocytes in alpha-1-antitrypsin deficiency with the genotype Pi--.

2. Genetic aspects of the Pi system.

3. Alpha 1 antitrypsinin the livers of patients with emphysema.

4. The genetics of alpha1-antitrypsin: a family study in England and Scotland.

5. Letter: Alpha1-antitrypsin deficiency.

6. Liver, lung and malignant disease in heterozygous (Pi MZ) alpha1-antitrypsin deficiency.

7. Alpha-1-antitrypsin bodies in the liver.

Review 8. The current status of alpha-1-antityrpsin, a protease inhibitor, in gastrointestinal disease.

9. Alpha 1 -antitrypsin (A1AT) accumulation in livers of emphysematous patients with A1AT deficiency.

1. The nature of cytoplasmic inclusions in cerebellar haemangioblastomas.

2. Alpha1-antitrypsin bodies, PiZ phenotype, and peptic ulcer.

3. Alpha-1-antitrypsin globules in the liver and PiM phenotype.

4. Alpha-1-antitrypsin Pi S phenotype and liver cell inclusion bodies in alcoholic hepatitis.

5. Demonstration of alpha 1-antitrypsin in paraffin sections of hepatoma and cirrhosis.

6. Aetiology of cirrhosis, hepatic fibrosis, and hepatocellular carcinoma.

7. Alpha-1-antitrypsin and the liver: a routine immunohistological screen.

8. Intra- and extracellular alpha 1-antitrypsin in liver disease with special reference to Pi phenotype.