Literature DB >> 3010996

Interferon alpha/beta selectively antagonises down-regulation of mannosyl-fucosyl receptors on activated macrophages by interferon gamma.

R A Ezekowitz, M Hill, S Gordon.   

Abstract

Previous reports have described synergism of various interferon preparations in anticellular and antiviral activity. We report that recombinant interferon (rIFN gamma) and IFN alpha/beta mediate distinct, antagonistic effects on expression of a lectin-like receptor for mannose and fucose (MFR) on mouse peritoneal macrophages (M phi). IFN gamma down-regulates MFR activity, a highly reproducible change in mouse M phi activated to secrete enhanced levels of o-2/H2o2. IFN alpha/beta enhances MFR activity and prevents the action of IFN gamma when added in combination. Antagonism is selective for this M phi activation marker and requires a minimum 4 h exposure period to rIFN gamma, during which IFN alpha/beta can prevent its action.

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Year:  1986        PMID： 3010996     DOI： 10.1016/0006-291x(86)90501-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

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Review 2.  The cellular receptor of the alpha-beta interferons.

Authors:  K E Mogensen; G Uzé; P Eid
Journal:  Experientia       Date:  1989-06-15

3.  Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease.

Authors:  R A Ezekowitz; S H Orkin; P E Newburger
Journal:  J Clin Invest       Date:  1987-10       Impact factor: 14.808

Review 4.  Interferon receptors.

Authors:  A A Branca
Journal:  In Vitro Cell Dev Biol       Date:  1988-03

5.  Impaired responsiveness to gamma interferon of macrophages infected with lymphocytic choriomeningitis virus clone 13: susceptibility to histoplasmosis.

Authors:  L Villarete; R de Fries; S Kolhekar; D Howard; R Ahmed; B Wu-Hsieh
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441

6.  Normal host defense during systemic candidiasis in mannose receptor-deficient mice.

Authors:  Sena J Lee; Nai-Ying Zheng; Monica Clavijo; Michel C Nussenzweig
Journal:  Infect Immun       Date:  2003-01       Impact factor: 3.441

7.  Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma.

Authors:  P E Newburger; R A Ezekowitz; C Whitney; J Wright; S H Orkin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

8.  Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

Authors:  M A Collart; D Belin; J D Vassalli; S de Kossodo; P Vassalli
Journal:  J Exp Med       Date:  1986-12-01       Impact factor: 14.307

9.  Agonist and antagonist effects of interferon alpha and beta on activation of human macrophages. Two classes of interferon gamma receptors and blockade of the high-affinity sites by interferon alpha or beta.

Authors:  R Yoshida; H W Murray; C F Nathan
Journal:  J Exp Med       Date:  1988-03-01       Impact factor: 14.307

10.  Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli.

Authors:  S S Rabinowitz; S Gordon
Journal:  J Exp Med       Date:  1991-10-01       Impact factor: 14.307
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