| Literature DB >> 30109565 |
Chieko Kawakita1,2, Masaru Kinomura3, Yoshie Gon4, Chika Okita5, Katsuyoshi Katayama3, Mana Nishikawa3, Noriaki Shimada3, Kenji Notohara5, Masaki Fukushima6, Kenichiro Asano3.
Abstract
A 40-year-old male was hospitalized with renal impairment and severe hypercalcemia. His concentration of serum IgG4 was high, but serum whole PTH, 1-25(OH)2 vitamin D3 and PTHrP were not elevated. Computed tomography showed swelling of the bilateral lacrimal glands and systemic lymphadenopathy. The histological findings of lacrimal gland biopsy fulfilled the diagnostic criteria of IgG4-related ophthalmic disease (IgG4ROD). Bone scintigraphy showed increased ectopic uptake in the stomach, heart, lungs, and kidneys. He died on day 16 of admission, although the therapies for hypercalcemia were continued. Autopsy results showed an increase of osteoclasts in the bone marrow and metastatic calcification in multiple organs, and excluded from the differential diagnosis other disorders which present lymph-node swelling and hypercalcemia such as cancer, lymphoma, Castleman's disease, and sarcoidosis. He was given a diagnosis of IgG4ROD with osteolytic hypercalcemia.Entities:
Keywords: Hypercalcemia; IgG4-related disease; Metastatic calcification
Mesh：
Year: 2018 PMID： 30109565 PMCID： PMC6361087 DOI： 10.1007/s13730-018-0358-6
Source DB: PubMed Journal: CEN Case Rep ISSN： 2192-4449