Literature DB >> 301092

Loss of surface IgD by human B lymphocytes during polyclonal activation.

J L Preudhomme.   

Abstract

Surface and cytoplasmic immunoglobulins were studied by direct immunofluorescence in pokeweed mitogen-stimulated cultures of human blood lymphocytes. The results compared to those of studies of unstimulated cultures and of fresh normal lymphocytes showed a striking decrease in surface IgD during terminal maturation of B lymphocytes into plasma cells. The number of cells which expressed IgG Fe receptor also decreased, although to a lesser extent.

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Year:  1977        PMID: 301092     DOI: 10.1002/eji.1830070316

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN: 0014-2980            Impact factor:   5.532


  3 in total

1.  Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms.

Authors:  K W Moore; J Rogers; T Hunkapiller; P Early; C Nottenburg; I Weissman; H Bazin; R Wall; L E Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

2.  Dysfunctions of pokeweed mitogen-stimulated T and B lymphocyte responses induced by gammaglobulin therapy.

Authors:  A Durandy; A Fischer; C Griscelli
Journal:  J Clin Invest       Date:  1981-03       Impact factor: 14.808

3.  Deoxyspergualin preferentially inhibits the growth and maturation of anti-CD40-activated surface IgD+ B lymphocytes.

Authors:  K Morikawa; K Nemoto; T Miyawaki; S Morikawa
Journal:  Clin Exp Immunol       Date:  1998-06       Impact factor: 4.330

  3 in total

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