Literature DB >> 30108757

Light-responsive CO2 bubble-generating polymeric micelles for tumor cell ablation.

Yifan Zhang1, Yuncai Guan1, Sizhan Ge1, Ahu Yuan1,2,3,4, Jinhui Wu1,5,2,3,4, Yiqiao Hu1,2,3,4.   

Abstract

We report a novel UV-responsive polymeric micelle system based on coumarin ester for tumor treatment. The micelle itself can generate CO2 under UV exposure owing to the photolysis of (7-diethylaminocoumarin-4-yl)methyl (DEACM). Without loading any drugs, the micelle causes significant cell death under 8 s UV irradiation in vitro. This is the first time to use light to decompose the nano-carrier itself into CO2 bubbles for tumor cell ablation.

Entities:  

Year:  2017        PMID： 30108757      PMCID： PMC6071738          DOI： 10.1039/c6md00625f

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  12 in total

1.  Light-responsive block copolymers.

Authors:  Jean-Marc Schumers; Charles-André Fustin; Jean-François Gohy
Journal:  Macromol Rapid Commun       Date:  2010-05-20       Impact factor: 5.734

2.  A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis.

Authors:  Min-Fan Chung; Ko-Jie Chen; Hsiang-Fa Liang; Zi-Xian Liao; Wei-Tso Chia; Younan Xia; Hsing-Wen Sung
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-05       Impact factor: 15.336

Review 3.  Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy.

Authors:  Petr Klán; Tomáš Šolomek; Christian G Bochet; Aurélien Blanc; Richard Givens; Marina Rubina; Vladimir Popik; Alexey Kostikov; Jakob Wirz
Journal:  Chem Rev       Date:  2012-12-21       Impact factor: 60.622

Review 4.  Photocontrolled nanoparticle delivery systems for biomedical applications.

Authors:  Akshaya Bansal; Yong Zhang
Journal:  Acc Chem Res       Date:  2014-08-19       Impact factor: 22.384

Review 5.  Advances in polymeric micelles for drug delivery and tumor targeting.

Authors:  Uttam Kedar; Prasanna Phutane; Supriya Shidhaye; Vilasrao Kadam
Journal:  Nanomedicine       Date:  2010-06-11       Impact factor: 5.307

6.  Coumarin-4-ylmethoxycarbonyls as phototriggers for alcohols and phenols.

Authors:  Akinobu Z Suzuki; Takayoshi Watanabe; Mika Kawamoto; Keiko Nishiyama; Hirotaka Yamashita; Megumi Ishii; Michiko Iwamura; Toshiaki Furuta
Journal:  Org Lett       Date:  2003-12-11       Impact factor: 6.005

7.  Temperature- and light-responsive smart polymer materials.

Authors:  Florian D Jochum; Patrick Theato
Journal:  Chem Soc Rev       Date:  2013-09-07       Impact factor: 54.564

8.  Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol.

Authors:  R D Olson; P S Mushlin; D E Brenner; S Fleischer; B J Cusack; B K Chang; R J Boucek
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

Review 9.  Therapeutic nanoparticles for drug delivery in cancer.

Authors:  Kwangjae Cho; Xu Wang; Shuming Nie; Zhuo Georgia Chen; Dong M Shin
Journal:  Clin Cancer Res       Date:  2008-03-01       Impact factor: 12.531

10.  CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation.

Authors:  Kun Zhang; Huixiong Xu; Hangrong Chen; Xiaoqing Jia; Shuguang Zheng; Xiaojun Cai; Ronghui Wang; Juan Mou; Yuanyi Zheng; Jianlin Shi
Journal:  Theranostics       Date:  2015-09-12       Impact factor: 11.556
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  1 in total

Review 1.  Physically stimulus-responsive nanoparticles for therapy and diagnosis.

Authors:  Fatemeh Farjadian; Soheila Ghasemi; Mohsen Akbarian; Mojtaba Hoseini-Ghahfarokhi; Mohsen Moghoofei; Mohammad Doroudian
Journal:  Front Chem       Date:  2022-09-14       Impact factor: 5.545
  1 in total

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