Literature DB >> 30107168

The role of cathepsin B in autophagy during obesity: A systematic review.

Thaís F Araujo1, André V Cordeiro2, Diogo A A Vasconcelos3, Kaio F Vitzel4, Vagner R R Silva5.   

Abstract

White adipose tissue (WAT) regulates energy homeostasis by releasing adipokines and modulating cell maintenance. Nutrient excess affects adipocyte hypertrophy directly in WAT by increasing excessively the activity of autophagy systems, generating proinflammatory markers and increasing infiltration of macrophages, causing metabolic diseases such as obesity and diabetes. Evidences suggest that cathepsin B (CTSB), a papain-like cysteine peptidase protein, can modulate autophagy processes in adipocytes. This review will focus on the role of CTSB in autophagy under conditions of obesity.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Autophagy; Cathepsin B; Obesity

Mesh：

Substances：

Year:  2018        PMID： 30107168     DOI： 10.1016/j.lfs.2018.08.024

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  4 in total

1.  Identification of Biomarkers of Autophagy-Related Genes Between Early and Advanced Carotid Atherosclerosis.

Authors:  Yuanyuan Zhang; He Zhang
Journal:  Int J Gen Med       Date:  2022-05-31

2.  Unraveling the role of salt-sensitivity genes in obesity with integrated network biology and co-expression analysis.

Authors:  Jamal Sabir M Sabir; Abdelfatteh El Omri; Babajan Banaganapalli; Nada Aljuaid; Abdulkader M Shaikh Omar; Abdulmalik Altaf; Nahid H Hajrah; Houda Zrelli; Leila Arfaoui; Ramu Elango; Mona G Alharbi; Alawiah M Alhebshi; Robert K Jansen; Noor A Shaik; Muhummadh Khan
Journal:  PLoS One       Date:  2020-02-06       Impact factor: 3.240

3.  Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype.

Authors:  Magdalena Rudzińska; Alessandro Parodi; Valentina D Maslova; Yuri M Efremov; Neonila V Gorokhovets; Vladimir A Makarov; Vasily A Popkov; Andrey V Golovin; Evgeni Y Zernii; Andrey A Zamyatnin
Journal:  Cancers (Basel)       Date:  2020-05-21       Impact factor: 6.639

4.  Vesicles Shed by Pathological Murine Adipocytes Spread Pathology: Characterization and Functional Role of Insulin Resistant/Hypertrophied Adiposomes.

Authors:  Tamara Camino; Nerea Lago-Baameiro; Susana B Bravo; Aurelio Sueiro; Iván Couto; Fernando Santos; Javier Baltar; Felipe F Casanueva; María Pardo
Journal:  Int J Mol Sci       Date:  2020-03-24       Impact factor: 5.923
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.