Satheesh Krishna1, Nicola Schieda2, Matthew Df McInnes1, Trevor A Flood3, Rebecca E Thornhill1. 1. Department of Medical Imaging, The Ottawa Hospital, The University of Ottawa, Ottawa, Ontario, Canada. 2. The Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada. nschieda@toh.on.ca. 3. Department of Anatomical Pathology, The Ottawa Hospital, The University of Ottawa, Ottawa, Ontario, Canada.
Abstract
PURPOSE: To assess T2-weighted (T2W) MRI to differentiate transition zone (TZ) prostate cancer (PCa) from benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: With IRB approval, 22 consecutive TZ PCa were retrospectively compared with 30 consecutive BPH (15 stromal, 15 glandular) nodules diagnosed using radical prostatectomy MRI maps. Two blinded radiologists (R1/R2) subjectively assessed the shape (round/oval vs. lenticular) and margin (circumscribed vs. blurred/indistinct) and for a T2W hypointense rim. Both radiologists segmented lesions extracting quantitative shape features (circularity, convexity and topology/skeletal branching). Statistical tests were performed using chi-square (subjective features), Mann-Whitney U (quantitative features), Cohen's kappa/Bland-Altman and receiver-operator characteristic analysis. RESULTS: There were differences in the subjective analysis of the shape, margin and absence of a T2W-rim comparing TZ PCa with BPH (p < 0.0001) with moderate to almost perfect agreement [kappa = 0.56 (shape), 0.72 (margin), 0.97 (T2W-rim)]. Area under the curve (AUC ± standard error) for diagnosis of TZ PCas was shape = 0.88 ± 0.05, margin = 0.89 ± 0.04, and T2W-rim = 0.91 ± 0.04. Shape, judged subjectively, was specific (100%/94% R1/R2) with low-to-moderate sensitivity (55%/88% R1/R2). Circularity and convexity differed between groups (p < 0.001) with no difference in topology/skeletal branches (p = 0.31). Agreement in measurements was substantial for significant quantitative variables and AUC ± SE, sensitivity and specificity for diagnosis of TZ PCa were: circularity = 0.98 ± 0.01, 90%/96%; convexity = 0.85 ± 0.06, 68%/97%. AUCs for circularity were higher than for subjective analysis (p = 0.01 and 0.26). CONCLUSION: Subjective analysis of T2W-MRI accurately diagnoses TZ PCa with high accuracy also demonstrated for quantitative shape analysis, which may be useful for future radiogenomic analysis of transition zone tumors. KEY POINTS: • Presence of a complete T2-weighted hypointense circumscribed rim accurately diagnoses BPH. • Round shape accurately diagnoses BPH and can be assessed quantitatively using circularity. • Lenticular shape accurately diagnoses TZ PCa and can be assessed quantitatively using convexity.
PURPOSE: To assess T2-weighted (T2W) MRI to differentiate transition zone (TZ) prostate cancer (PCa) from benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: With IRB approval, 22 consecutive TZ PCa were retrospectively compared with 30 consecutive BPH (15 stromal, 15 glandular) nodules diagnosed using radical prostatectomy MRI maps. Two blinded radiologists (R1/R2) subjectively assessed the shape (round/oval vs. lenticular) and margin (circumscribed vs. blurred/indistinct) and for a T2W hypointense rim. Both radiologists segmented lesions extracting quantitative shape features (circularity, convexity and topology/skeletal branching). Statistical tests were performed using chi-square (subjective features), Mann-Whitney U (quantitative features), Cohen's kappa/Bland-Altman and receiver-operator characteristic analysis. RESULTS: There were differences in the subjective analysis of the shape, margin and absence of a T2W-rim comparing TZ PCa with BPH (p < 0.0001) with moderate to almost perfect agreement [kappa = 0.56 (shape), 0.72 (margin), 0.97 (T2W-rim)]. Area under the curve (AUC ± standard error) for diagnosis of TZ PCas was shape = 0.88 ± 0.05, margin = 0.89 ± 0.04, and T2W-rim = 0.91 ± 0.04. Shape, judged subjectively, was specific (100%/94% R1/R2) with low-to-moderate sensitivity (55%/88% R1/R2). Circularity and convexity differed between groups (p < 0.001) with no difference in topology/skeletal branches (p = 0.31). Agreement in measurements was substantial for significant quantitative variables and AUC ± SE, sensitivity and specificity for diagnosis of TZ PCa were: circularity = 0.98 ± 0.01, 90%/96%; convexity = 0.85 ± 0.06, 68%/97%. AUCs for circularity were higher than for subjective analysis (p = 0.01 and 0.26). CONCLUSION: Subjective analysis of T2W-MRI accurately diagnoses TZ PCa with high accuracy also demonstrated for quantitative shape analysis, which may be useful for future radiogenomic analysis of transition zone tumors. KEY POINTS: • Presence of a complete T2-weighted hypointense circumscribed rim accurately diagnoses BPH. • Round shape accurately diagnoses BPH and can be assessed quantitatively using circularity. • Lenticular shape accurately diagnoses TZ PCa and can be assessed quantitatively using convexity.
Entities:
Keywords:
Benign prostatic hyperplasia; Magnetic resonance imaging; Medical imaging; Prostate; Prostate cancer
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