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Literature DB >> 301053

Sterol content and polyene antibiotic resistance in isolates of Candida krusei, Candida parakrusei, and Candida tropicalis.

L M Safe, S H Safe, R E Subden, D C Morris.

Abstract

Three isolates, one from each species of Candida krusei, C. parakrusei, and C. tropicalis, obtained from infected patients, were more tolerant of significantly higher concentrations of polyene antibiotics than the corresponding reference wild types. The resistant strains isolated had the same sterols as their wild-type counterparts but in lower concentrations.

Entities: Chemical Disease Species

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Year: 1977 PMID： 301053 DOI： 10.1139/m77-058

Source DB: PubMed Journal: Can J Microbiol ISSN： 0008-4166 Impact factor: 2.419

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Cited

15 in total

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Journal: Antimicrob Agents Chemother Date: 2014-08-25 Impact factor: 5.191

2. Efficacy of LY303366 against amphotericin B-susceptible and -resistant Aspergillus fumigatus in a murine model of invasive aspergillosis.

Authors: P E Verweij; K L Oakley; J Morrissey; G Morrissey; D W Denning
Journal: Antimicrob Agents Chemother Date: 1998-04 Impact factor: 5.191

7. Isolation, structural and toxicological characterization of three new mycotoxins produced by the fungusAureobasidium pullulans.

Authors: A Schrattenholz; P Flesch
Journal: Mycotoxin Res Date: 1993-03 Impact factor: 3.833

Sterol content and polyene antibiotic resistance in isolates of Candida krusei, Candida parakrusei, and Candida tropicalis.

1. The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug.

2. Efficacy of LY303366 against amphotericin B-susceptible and -resistant Aspergillus fumigatus in a murine model of invasive aspergillosis.

3. Trichosporon beigelii, an emerging pathogen resistant to amphotericin B.

Review 4. Treatment of systemic fungal infections: recent progress and current problems.

5. Development of resistance to amphotericin B in Candida lusitaniae infecting a human.

Review 6. Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches.

7. Isolation, structural and toxicological characterization of three new mycotoxins produced by the fungusAureobasidium pullulans.

Review 8. Drug resistance in human pathogenic fungi.

9. Isolation and characterization of a polyene-resistant variant of Candida tropicalis.

Review 10. Emergence of a new opportunistic pathogen, Candida lusitaniae.