| Literature DB >> 30104077 |
Fatemeh Dousti1, Arman Shahrisa2, Hossein Ansari3, Mohammadreza Hajjari4, Yaser Tahmasebi Birgani5, Javad Mohammadiasl6, Maryam Tahmasebi Birgani7.
Abstract
Long non-coding RNAs (lncRNAs), are lengthy noncoding transcripts with pivotal roles in biological pathways including cell cycle, apoptosis and chromatin remodeling. Aberrant expression of lncRNAs has been strongly connected with tumor progression and metastasis. However, the prognostic significance of lncRNAs in diffuse large-B-cell lymphoma (DLBCL) remains unclear. In this study, the expression levels of 189 approved lncRNAs were considered in DLBCL patients using several different genomic and transcriptome datasets. The analyses showed that the lncRNA GAS5 allocated the maximum score of RNA dysregulation and can be considered as good choice in DLBCLs' researches.Entities:
Keywords: Bioinformatics analysis; Biomarker; Diffuse large-B-cell lymphoma; GAS5; Long noncoding RNA
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Year: 2018 PMID： 30104077 DOI： 10.1016/j.prp.2018.08.006
Source DB: PubMed Journal: Pathol Res Pract ISSN： 0344-0338 Impact factor: 3.250