Binay Kayan Ocakoglu1, Neslihan Edeer Karaca2, Fevzi Tuna Ocakoglu1, Serpil Erermis3. 1. Child Psychiatry Outpatient Clinic, Batman District State Hospital, Batman, Turkey. 2. Department of Pediatric Immunology and Rheumatology, Ege University School of Medicine, Bornova, Izmir, Turkey. 3. Department of Child and Adolescent Psychiatry, Ege University School of Medicine, Bornova, Izmir, Turkey.
Abstract
BACKGROUND: Primary immunodeficiency disorder (PID), being a chronic disorder, may increase the prevalence of psychopathologies, but there are few studies on the effect of disease-related factors on psychopathology in this population. The aim of this study was therefore to assess and compare three groups: children with PID who receive i.v. immunoglobulin treatment; children with juvenile idiopathic arthritis (JIA); and healthy controls with respect to their mental health status. METHODS: Forty-four children with PID, 32 children with JIA and 30 healthy controls, underwent psychiatric evaluation. The Childhood Depression Inventory and the screen for child anxiety-related emotional disorders questionnaire were completed by the participants. The child behavior checklist was completed by the mothers of the participants. In addition, disease-related factors were identified. RESULTS: The frequency of mood disorders between the three groups differed. There was no difference between the PID and JIA groups with respect to the prevalence of mood disorders and other psychopathologies. The disease-related factors were associated with the frequency of mood disorder in PID patients. CONCLUSION: The rate of psychopathology was similar in patients with PID and JIA and higher than the controls. Some of the disease-related factors were associated with the frequency of mood disorders in the PID patients.
BACKGROUND:Primary immunodeficiency disorder (PID), being a chronic disorder, may increase the prevalence of psychopathologies, but there are few studies on the effect of disease-related factors on psychopathology in this population. The aim of this study was therefore to assess and compare three groups: children with PID who receive i.v. immunoglobulin treatment; children with juvenile idiopathic arthritis (JIA); and healthy controls with respect to their mental health status. METHODS: Forty-four children with PID, 32 children with JIA and 30 healthy controls, underwent psychiatric evaluation. The Childhood Depression Inventory and the screen for childanxiety-related emotional disorders questionnaire were completed by the participants. The child behavior checklist was completed by the mothers of the participants. In addition, disease-related factors were identified. RESULTS: The frequency of mood disorders between the three groups differed. There was no difference between the PID and JIA groups with respect to the prevalence of mood disorders and other psychopathologies. The disease-related factors were associated with the frequency of mood disorder in PID patients. CONCLUSION: The rate of psychopathology was similar in patients with PID and JIA and higher than the controls. Some of the disease-related factors were associated with the frequency of mood disorders in the PID patients.
Authors: Ines Serra; Olivia R Manusama; Fabian M P Kaiser; Izi Izumi Floriano; Lucas Wahl; Christian van der Zalm; Hanna IJspeert; P Martin van Hagen; Nico J M van Beveren; Sandra M Arend; Klaus Okkenhaug; Johan J M Pel; Virgil A S H Dalm; Aleksandra Badura Journal: Brain Behav Immun Health Date: 2021-10-19