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Literature DB >> 30103043

Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT).

Lubica Rauova¹, Gowthami Arepally², Mortimer Poncz¹, Douglas B Cines³.

Abstract

Entities: Chemical Disease Gene Species

Year: 2018 PMID： 30103043 PMCID： PMC6201246 DOI： 10.1016/j.autrev.2018.05.003

Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754

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49 in total

1. Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages.

Authors: M Joglekar; S Khandelwal; D B Cines; M Poncz; L Rauova; G M Arepally
Journal: J Thromb Haemost Date: 2015-07-14 Impact factor: 5.824

2. Heparin-induced thrombocytopenia type II in a surgical intensive care unit.

Authors: Yasser Sakr; Friederike Haetscher; Mateus Demarchi Gonsalves; Michael Hoffman; Bernhard Theis; Dagmar Barz; Konrad Reinhart; Andreas Kortgen
Journal: J Crit Care Date: 2011-08-19 Impact factor: 3.425

3. Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia.

Authors: Bruce S Sachais; Ann H Rux; Douglas B Cines; Serge V Yarovoi; Lee I Garner; Stephen P Watson; Jillian L Hinds; John J Rux
Journal: Blood Date: 2012-03-27 Impact factor: 22.113

Review 4. Heparin-induced thrombocytopenia.

Authors: Gowthami M Arepally
Journal: Blood Date: 2017-04-17 Impact factor: 22.113

5. Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4.

Authors: Rustem I Litvinov; Serge V Yarovoi; Lubica Rauova; Valeri Barsegov; Bruce S Sachais; Ann H Rux; Jillian L Hinds; Gowthami M Arepally; Douglas B Cines; John W Weisel
Journal: J Biol Chem Date: 2013-10-04 Impact factor: 5.157

Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT).

1. Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages.

2. Heparin-induced thrombocytopenia type II in a surgical intensive care unit.

3. Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia.

Review 4. Heparin-induced thrombocytopenia.

5. Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4.

6. Argatroban anticoagulation in patients with heparin-induced thrombocytopenia.

7. Polyphosphates form antigenic complexes with platelet factor 4 (PF4) and enhance PF4-binding to bacteria.

Review 8. Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT).

9. Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia.

10. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.

1. Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation.