| Literature DB >> 301025 |
F C Arnett, B Z Schacter, M C Hochberg, S H Hsu, W B Bias.
Abstract
The effect of homozygosity for HLA-B27 on the clinical expression of rheumatic disease was studied in two families. The 1 homozygous patient in each of two families demonstrated extraordinarily severe peripheral and axial arthritis compared to other affected heterozygous relatives. In addition, predominant peripheral or axial disease appeared to segregate with different B27 haplotypes. The 2 homozygous patients were not homozygous at the hla-a,c, or D loci.Entities:
Mesh：
Substances：
Year: 1977 PMID： 301025 DOI： 10.1002/art.1780200306
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591