Experimental and clinical studies on the effects of synthetic muramyldipeptide derivatives on viral and opportunistic infections.

The efficacy of strearoyl-MDP derivatives, L18-MDP and MDP-Lys-18 against bacterial and viral infections in mice was examined. Both L18-MDP and MDP-Lys-L18 stimulated nonspecifically host-resistance against opportunistic infection with C. kutscheri in hydrocrotisone-treated mice against Sendai virus infection in mice.