| Literature DB >> 30099739 |
Cinthia Nóbrega de Sousa Dias1, Bruna Macêdo Gois1, Viviane Silva Lima1, Isabel Cristina Guerra-Gomes1, Josélio Maria Galvão Araújo2, Juliana de Assis Silva Gomes3, Demétrius Antônio Machado Araújo4, Isac Almeida Medeiros5, Fátima de Lourdes Assunção Araújo de Azevedo5, Robson Cavalcanti Veras5, Daniele Idalino Janebro1, Ian Porto Gurgel do Amaral6, Tatjana Souza Lima Keesen1,6.
Abstract
There is a need for more detailed elucidation of T-cell immunity in chikungunya infection. CD8 T cells are one of main actors against viruses. Here, we analysed CD8+ T lymphocytes from patients in the acute and chronic phases of chikungunya disease (CHIKD). Our results demonstrate that CD8+ T cells expressed higher ex vivo granzyme B, perforin and CD107A expression in patients in the acute phase of CHIKD compared with healthy individuals and higher ex vivo expression of CD69, interleukin-17A, interleukin-10 and CD95 ligand, and co-expression of CD95/CD95 ligand. These results elucidate the importance of these lymphocytes, demonstrating immune mechanisms mediated in human chikungunya infection.Entities:
Keywords: CD8 T-cell; activation; chikungunya infection; cytokines; human
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Year: 2018 PMID： 30099739 PMCID： PMC6231013 DOI： 10.1111/imm.12992
Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397