Effect of ursodeoxycholic acid on glycemic markers: A systematic review and meta-analysis of clinical trials.

Ursodeoxycholic acid (UDCA) is widely used to treat liver diseases; however, its potential effect on metabolic parameters has been poorly investigated. Additionally, owing to divergent data, the objective of this meta-analysis was to evaluate the effect of UDCA on glycemic parameters in clinical trials. Clinical trials investigating the impact of UDCA treatment on glycemic markers were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases (from inception to April 16, 2018). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on glycemic parameters. Meta-analysis of seven studies comprising eight treatment arms revealed a significant reduction of fasting glucose levels following UDCA therapy (WMD: -3.30 mg/dL, 95% CI: -6.36, -0.24, p = 0.034; I2 = 28.95%). Also, meta-analysis of two treatment arms indicated a significant reduction of glycated hemoglobin (HbA1c) concentrations (WMD: -0.41% mg/dL, 95% CI: -0.81, -0.01, p = 0.042; I2 = 0%). Additionally, meta-analysis of four treatment arms also revealed a significant reduction in plasma insulin levels (WMD: -1.50 mg/dL, 95% CI: -2.81, -0.19, p = 0.025; I2 = 67.90%) but not significant effect HOMA-IR (WMD: -0.20 mg/dL, 95% CI: -0.42, 0.01, p = 0.057; I2 = 85.34%). Results of this meta-analysis showed that UDCA significantly reduces fasting plasma glucose, HbA1c, and insulin concentrations suggesting a positive impact on glucose homeostasis.