Atsushi Tanaka1, Kohta Suzuki2, Motoi Nagayoshi3, Akihiro Tanaka3, Youichi Takemoto3, Seiji Watanabe4, Satoru Takeda5, Minoru Irahara6, Naoaki Kuji7, Zentaro Yamagata8, Ryuzo Yanagimachi9. 1. Saint Mother Obstetrics and Gynecology Clinic and Institute for Assisted Reproductive Technologies, Fukuoka, Japan. Electronic address: incho@stmother.com. 2. Department of Health and Psychosocial Medicine, Aichi Medical University School of Medicine, Aichi, Japan. 3. Saint Mother Obstetrics and Gynecology Clinic and Institute for Assisted Reproductive Technologies, Fukuoka, Japan. 4. Department of Anatomic Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. 5. Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan. 6. Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan. 7. Department of Obstetrics and Gynecology, Tokyo Medical College, Tokyo, Japan. 8. Basic Science for Clinical Medicine, Division of Medicine, Graduate School Department of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan. 9. University of Hawaii Medical School, Honolulu, Hawaii.
Abstract
OBJECTIVE: To compare physical and cognitive development of babies born after round spermatid injection (ROSI) with those born after natural conception. DESIGN: Comparison of efficiencies of ROSI and ICSI using testicular spermatozoa, performed in the St. Mother Clinic. Physical and cognitive development of ROSI babies recorded by parents in the government-issued Mother-Child Handbook was checked and verified by attending pediatricians. Data included baby's weight gain and response to parents' voice/gesture. SETTING: Assisted reproduction technology practice. PATIENT(S): A total of 721 men participated in ROSI; 90 ROSI babies were followed for 2 years for their physical and cognitive development. Control subjects were 1,818 naturally born babies. INTERVENTION(S): Surgical retrieval of spermatogenic cells from testes; selection and injection of round spermatids into oocytes; oocyte activation, in vitro culture of fertilized eggs, and embryo transfer to mothers. MAIN OUTCOME MEASURE(S): Physical and cognitive development of ROSI babies (e.g., body weight increase, response to parents, and understanding and speaking simple language) compared with naturally born babies. RESULT(S): Of 90 ROSI babies, three had congenital aberrations at birth, which corrected spontaneously (ventricular septa) or after surgery (cleft lip and omphalocele). Physical and cognitive development of ROSI babies was similar to those of naturally born babies. CONCLUSION(S): There were no significant differences between ROSI and naturally conceived babies in either physical or cognitive development during the first 2 years after birth. CLINICAL TRIAL REGISTRATION NUMBER: UMIN Clinical Trials Registry UMIN000006117.
OBJECTIVE: To compare physical and cognitive development of babies born after round spermatid injection (ROSI) with those born after natural conception. DESIGN: Comparison of efficiencies of ROSI and ICSI using testicular spermatozoa, performed in the St. Mother Clinic. Physical and cognitive development of ROSI babies recorded by parents in the government-issued Mother-Child Handbook was checked and verified by attending pediatricians. Data included baby's weight gain and response to parents' voice/gesture. SETTING: Assisted reproduction technology practice. PATIENT(S): A total of 721 men participated in ROSI; 90 ROSI babies were followed for 2 years for their physical and cognitive development. Control subjects were 1,818 naturally born babies. INTERVENTION(S): Surgical retrieval of spermatogenic cells from testes; selection and injection of round spermatids into oocytes; oocyte activation, in vitro culture of fertilized eggs, and embryo transfer to mothers. MAIN OUTCOME MEASURE(S): Physical and cognitive development of ROSI babies (e.g., body weight increase, response to parents, and understanding and speaking simple language) compared with naturally born babies. RESULT(S): Of 90 ROSI babies, three had congenital aberrations at birth, which corrected spontaneously (ventricular septa) or after surgery (cleft lip and omphalocele). Physical and cognitive development of ROSI babies was similar to those of naturally born babies. CONCLUSION(S): There were no significant differences between ROSI and naturally conceived babies in either physical or cognitive development during the first 2 years after birth. CLINICAL TRIAL REGISTRATION NUMBER: UMIN Clinical Trials Registry UMIN000006117.
Authors: Sujittra Khampang; In Ki Cho; Kanchana Punyawai; Brittany Gill; Jacqueline N Langmo; Shivangi Nath; Katherine W Greeson; Krista M Symosko; Kristen L Fowler; Siran Tian; John P Statz; Alyse N Steves; Rangsun Parnpai; Michael A White; Jon D Hennebold; Kyle E Orwig; Calvin R Simerly; Gerald Schatten; Charles A Easley Journal: F S Sci Date: 2021-09-08
Authors: Brent M Hanson; Taylor P Kohn; Alexander W Pastuszak; Richard T Scott; Philip J Cheng; James M Hotaling Journal: Asian J Androl Date: 2021 Jul-Aug Impact factor: 3.285