Ryuji Ohashi1, Shigeki Namimatsu1, Takashi Sakatani1,2, Zenya Naito1,2, Hiroyuki Takei3, Akira Shimizu1,4. 1. Department of Diagnostic Pathology, Nippon Medical School Hospital, Tokyo, Japan. 2. Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, Japan. 3. Department of Breast Surgery, Nippon Medical School Hospital, Tokyo, Japan. 4. Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan.
Abstract
BACKGROUND AND OBJECTIVES: Emerging evidence suggests that the presence of atypical mitoses is associated with poor prognosis in some types of cancer, but its clinical significance remains uncertain. Here, we investigated the occurrence of atypical mitoses in breast cancers. METHODS: Mitotic figures, including normal and atypical mitoses, were assessed in resected histological sections from 109 patients with invasive carcinoma of no special type (ICNST). Comparisons with clinicopathological features and biomarkers such as Ki67 and phosphohistone H3 (PHH3) were performed. RESULTS: The total number of mitotic figures, including atypical mitoses, was higher in situ and invasive ductal carcinoma components than in normal ducts. Morphological characteristics of atypical mitoses included multipolar, lagged, ring, asymmetrical mitoses, and anaphase bridge. Patients with higher total mitoses and PHH3, and the presence of atypical mitoses showed reduced overall survival (OS), compared to those with lower total mitoses and PHH3, and without atypical mitoses (P = 0.03, 0.02, and <0.001, respectively). In multivariate analysis, the presence of atypical mitoses alone attained significant correlation with shorter OS (P < 0.001). CONCLUSIONS: Atypical mitoses in routinely resected specimens have a robust prognostic value for ICNST of the breast, but its clinical utility remains to be validated in a multicenter large material.
BACKGROUND AND OBJECTIVES: Emerging evidence suggests that the presence of atypical mitoses is associated with poor prognosis in some types of cancer, but its clinical significance remains uncertain. Here, we investigated the occurrence of atypical mitoses in breast cancers. METHODS: Mitotic figures, including normal and atypical mitoses, were assessed in resected histological sections from 109 patients with invasive carcinoma of no special type (ICNST). Comparisons with clinicopathological features and biomarkers such as Ki67 and phosphohistone H3 (PHH3) were performed. RESULTS: The total number of mitotic figures, including atypical mitoses, was higher in situ and invasive ductal carcinoma components than in normal ducts. Morphological characteristics of atypical mitoses included multipolar, lagged, ring, asymmetrical mitoses, and anaphase bridge. Patients with higher total mitoses and PHH3, and the presence of atypical mitoses showed reduced overall survival (OS), compared to those with lower total mitoses and PHH3, and without atypical mitoses (P = 0.03, 0.02, and <0.001, respectively). In multivariate analysis, the presence of atypical mitoses alone attained significant correlation with shorter OS (P < 0.001). CONCLUSIONS: Atypical mitoses in routinely resected specimens have a robust prognostic value for ICNST of the breast, but its clinical utility remains to be validated in a multicenter large material.
Authors: Agnieszka Walczyk; Janusz Kopczyński; Danuta Gąsior-Perczak; Iwona Pałyga; Artur Kowalik; Magdalena Chrapek; Maria Hejnold; Stanisław Góźdź; Aldona Kowalska Journal: PLoS One Date: 2020-02-24 Impact factor: 3.240
Authors: Ayat Lashen; Michael S Toss; Mansour Alsaleem; Andrew R Green; Nigel P Mongan; Emad Rakha Journal: Mod Pathol Date: 2022-05-02 Impact factor: 8.209