THE AIM: The aim of this study was to analyze factors associated with quality of life (QoL) after ileal pouch anal anastomosis (IPAA). METHODS: Patients who underwent IPAA (1983-2015) and replied to QoL questionnaire were identified from an IRB-approved prospectively maintained IPAA-database. QoL was assessed using Cleveland Global Quality of Life (CGQL) questionnaire at 1, 3, 5, and 10 years postoperatively. Patient cohort was divided in two groups: overall QoL score ≤ 0.7 (low) and > 0.7 (high). Demographics, perioperative morbidity, and functional results were analyzed. RESULTS: A total of 4059 patients replied to the questionnaire at the most recent follow-up and were included. A total of 2889 (71%) had overall QoL > 0.7 (group 1) and 1170 (29%) patients had overall QoL ≤ 0.7 (group 2). Patients in group 1 had lower rates of early (44.6 vs. 50.4%, p = 0.003) and late (55.7 vs. 64.5%, p < 0.003) postoperative complications. Kaplan-Meier survival analysis demonstrated significantly higher rates of pouch failure among patients with lower QoL. Pouchitis, obstruction, fistulas, higher number of stools, and IPAA performed during the most recent decade (2005-2015) were significantly associated with lower QoL (≤ 0.7), while S-pouch configuration was associated with higher QoL (> 0.7). CONCLUSION: Patient's characteristics and minimal perioperative complications impact patient's QoL following IPAA not only in the short term, but also in the long term.
THE AIM: The aim of this study was to analyze factors associated with quality of life (QoL) after ileal pouch anal anastomosis (IPAA). METHODS:Patients who underwent IPAA (1983-2015) and replied to QoL questionnaire were identified from an IRB-approved prospectively maintained IPAA-database. QoL was assessed using Cleveland Global Quality of Life (CGQL) questionnaire at 1, 3, 5, and 10 years postoperatively. Patient cohort was divided in two groups: overall QoL score ≤ 0.7 (low) and > 0.7 (high). Demographics, perioperative morbidity, and functional results were analyzed. RESULTS: A total of 4059 patients replied to the questionnaire at the most recent follow-up and were included. A total of 2889 (71%) had overall QoL > 0.7 (group 1) and 1170 (29%) patients had overall QoL ≤ 0.7 (group 2). Patients in group 1 had lower rates of early (44.6 vs. 50.4%, p = 0.003) and late (55.7 vs. 64.5%, p < 0.003) postoperative complications. Kaplan-Meier survival analysis demonstrated significantly higher rates of pouch failure among patients with lower QoL. Pouchitis, obstruction, fistulas, higher number of stools, and IPAA performed during the most recent decade (2005-2015) were significantly associated with lower QoL (≤ 0.7), while S-pouch configuration was associated with higher QoL (> 0.7). CONCLUSION:Patient's characteristics and minimal perioperative complications impact patient's QoL following IPAA not only in the short term, but also in the long term.
Entities:
Keywords:
Ileal pouch anal anastomosis; Inflammatory bowel disease; Quality of life
Authors: Matthias Turina; Connie J Pennington; Jennifer Kimberling; Arnold J Stromberg; Robert E Petras; Susan Galandiuk Journal: J Gastrointest Surg Date: 2006-04 Impact factor: 3.452
Authors: C Y Ko; L C Rusin; D J Schoetz; L Moreau; J C Coller; J J Murray; P L Roberts; P W Marcello Journal: J Surg Res Date: 2001-06-15 Impact factor: 2.192
Authors: Fabrizio Michelassi; John Lee; Michele Rubin; Alessandro Fichera; Kristen Kasza; Theodore Karrison; Roger D Hurst Journal: Ann Surg Date: 2003-09 Impact factor: 12.969
Authors: Ravi P Kiran; Conor P Delaney; Anthony J Senagore; Bridget O'Brien-Ermlich; Edward Mascha; Julie Thornton; Victor W Fazio Journal: Am J Gastroenterol Date: 2003-08 Impact factor: 10.864
Authors: Edward L Barnes; Laura Raffals; Millie D Long; Gaurav Syal; Maia Kayal; Ashwin Ananthakrishnan; Benjamin Cohen; Joel Pekow; Parakkal Deepak; Jean-Frederic Colombel; Hans H Herfarth; Robert S Sandler Journal: Crohns Colitis 360 Date: 2020-07-24