| Literature DB >> 30097236 |
F De Felice1, C Marchetti2, I Palaia3, R Ostuni3, L Muzii3, V Tombolini1, P Benedetti Panici3.
Abstract
Despite different treatment strategies, locally advanced cervical cancer (CC) persists as one of the most incurable cancers among women worldwide. In fact, this setting of patients are at high risk of persistent and recurrent disease. In recent years, researches have investigated immune check-point inhibitors in hopes of determining improved response to therapy with prolongation of survival. We reviewed the published literature and conference proceedings and presented pivotal trials supporting immune check-point inhibitors use in the treatment of CC.Entities:
Keywords: CTLA-4; Cervical cancer; Immune check-point; Immunotherapy; Ipilimumab; Nivolumab; PD-1; Pembrolizumab
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Year: 2018 PMID: 30097236 DOI: 10.1016/j.critrevonc.2018.06.006
Source DB: PubMed Journal: Crit Rev Oncol Hematol ISSN: 1040-8428 Impact factor: 6.312