Ryszard Pluta1, Anna Bogucka-Kocka2, Marzena Ułamek-Kozioł3, Jacek Bogucki4, Sławomir Januszewski5, Janusz Kocki4, Stanisław J Czuczwar6. 1. Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland. Electronic address: pluta@imdik.pan.pl. 2. Department of Biology and Genetics, Medical University of Lublin, Lublin, Poland. 3. Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland; First Department of Neurology, Institute of Psychiatry and Neurology, Warszawa, Poland. 4. Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland. 5. Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland. 6. Department of Pathophysiology, Medical University of Lublin, Lublin, Poland; Department of Physiopathology, Institute of Rural Health, Lublin, Poland. Electronic address: czuczwarsj@yahoo.com.
Abstract
BACKGROUND: Tauopathies are a class of neurodegenerative illnesses associated with the aberrant accumulation of the tau protein in the brain. The best known out of these diseases is Alzheimer's disease, a disorder where the microtubule associated tau protein becomes hyperphosphorylated (which lowers its binding affinity to microtubules) and accumulates inside neurons in the form of tangles. In this study, we attempt to find out whether brain ischemia may play an important role in tau protein gene alterations. METHODS: We have investigated the relationship between hippocampal ischemia and Alzheimer's disease by means of a transient 10-min global brain ischemia in rats and determining the effect on Alzheimer's disease tau protein gene expression during 2, 7 and 30 days post injury. RESULTS: We found the significant overexpression of tau protein gene on the 2nd day, but on day's 7 and 30 post-ischemia there a significant opposite tendency was observed. CONCLUSION: The obtained results offer a novel insight into tau protein gene in regulating delayed neuronal death in the ischemic hippocampus. Finally, these findings further elucidate the long-term impact of brain ischemia on Alzheimer's disease development.
BACKGROUND:Tauopathies are a class of neurodegenerative illnesses associated with the aberrant accumulation of the tau protein in the brain. The best known out of these diseases is Alzheimer's disease, a disorder where the microtubule associated tau protein becomes hyperphosphorylated (which lowers its binding affinity to microtubules) and accumulates inside neurons in the form of tangles. In this study, we attempt to find out whether brain ischemia may play an important role in tau protein gene alterations. METHODS: We have investigated the relationship between hippocampal ischemia and Alzheimer's disease by means of a transient 10-min global brain ischemia in rats and determining the effect on Alzheimer's disease tau protein gene expression during 2, 7 and 30 days post injury. RESULTS: We found the significant overexpression of tau protein gene on the 2nd day, but on day's 7 and 30 post-ischemia there a significant opposite tendency was observed. CONCLUSION: The obtained results offer a novel insight into tau protein gene in regulating delayed neuronal death in the ischemic hippocampus. Finally, these findings further elucidate the long-term impact of brain ischemia on Alzheimer's disease development.
Authors: Maria Kovalska; Barbara Tothova; Libusa Kovalska; Zuzana Tatarkova; Dagmar Kalenska; Anna Tomascova; Marian Adamkov; Jan Lehotsky Journal: Neurochem Res Date: 2018-07-12 Impact factor: 3.996
Authors: Marzena Ułamek-Kozioł; Stanisław Jerzy Czuczwar; Sławomir Januszewski; Ryszard Pluta Journal: Int J Mol Sci Date: 2020-01-30 Impact factor: 5.923
Authors: Marzena Ułamek-Kozioł; Stanisław J Czuczwar; Janusz Kocki; Sławomir Januszewski; Jacek Bogucki; Anna Bogucka-Kocka; Ryszard Pluta Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472