| Literature DB >> 30096309 |
Michael P Murphy1, Luke A J O'Neill2.
Abstract
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.Entities:
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Year: 2018 PMID： 30096309 DOI： 10.1016/j.cell.2018.07.030
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582