Literature DB >> 3009548

Human monoclonal autoantibodies that react with both pancreatic islets and thyroid.

C Garzelli, F E Taub, M C Jenkins, D W Drell, F Ginsberg-Fellner, A L Notkins.   

Abstract

Transformation of human peripheral blood lymphocytes with Epstein-Barr virus and rapid screening on rat insulinoma cells by an enzyme-linked immunosorbent assay were used to identify monoclonal autoantibodies that reacted with human pancreatic islets. Six such monoclonal autoantibodies were isolated and cloned. All six also were found to react with human thyroid. It is concluded that lymphocytes able to make autoantibodies that react with both the pancreas and thyroid are common in the human B cell repertoire.

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Year:  1986        PMID： 3009548      PMCID： PMC424567          DOI： 10.1172/JCI112479

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  28 in total

1.  Immunological specificity, unique combinations of selected natural globulins provide an alternative to the classical concept.

Authors:  D W TALMAGE
Journal:  Science       Date:  1959-06-19       Impact factor: 47.728

2.  Separation of T and B lymphocytes by nylon wool columns: evaluation of efficacy by functional assays in vivo.

Authors:  D Trizio; G Cudkowicz
Journal:  J Immunol       Date:  1974-10       Impact factor: 5.422

Review 3.  Speculations. How specific are antibodies?

Authors:  F F Richards; W H Konigsberg
Journal:  Immunochemistry       Date:  1973-08

4.  Diabetes mellitus: the incidence of circulating antibodies against thyroid, gastric, and adrenal tissue.

Authors:  D E Goldstein; A Drash; J Gibbs; R M Blizzard
Journal:  J Pediatr       Date:  1970-08       Impact factor: 4.406

Review 5.  On the specificity of antibodies.

Authors:  F F Richards; W H Konigsberg; R W Rosenstein; J M Varga
Journal:  Science       Date:  1975-01-17       Impact factor: 47.728

6.  Release of infectious Epstein-Barr virus by transformed marmoset leukocytes.

Authors:  G Miller; M Lipman
Journal:  Proc Natl Acad Sci U S A       Date:  1973-01       Impact factor: 11.205

7.  Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids.

Authors:  E M Lafer; J Rauch; C Andrzejewski; D Mudd; B Furie; B Furie; R S Schwartz; B D Stollar
Journal:  J Exp Med       Date:  1981-04-01       Impact factor: 14.307

8.  Lymphocytotoxic antibodies and histocompatibility antigens in juvenile-onset diabetes mellitus.

Authors:  S Serjeantson; J Theophilus; P Zimmet; J Court; J R Crossley; R B Elliott
Journal:  Diabetes       Date:  1981-01       Impact factor: 9.461

9.  Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.

Authors:  A F Gazdar; W L Chick; H K Oie; H L Sims; D L King; G C Weir; V Lauris
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

10.  Organ-specific autoantibodies in children with common endocrine diseases.

Authors:  G M Bright; R M Blizzard; D L Kaiser; W L Clarke
Journal:  J Pediatr       Date:  1982-01       Impact factor: 4.406
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  5 in total

1.  Production of human monoclonal anti-basement membrane zone (BMZ) antibodies from a patient with bullous pemphigoid (BP) by Epstein-Barr virus transformation. Analyses of the heterogeneity of anti-BMZ antibodies in BP sera using them.

Authors:  T Sugi; T Hashimoto; T Hibi; T Nishikawa
Journal:  J Clin Invest       Date:  1989-10       Impact factor: 14.808

2.  Reactivity of monoclonal islet cell antibodies on normal hyperplastic and neoplastic thyroid C-cells.

Authors:  N Neuhold; M Wimmer; O M Braun; G Horvat; K Krisch
Journal:  Cell Tissue Res       Date:  1989-08       Impact factor: 5.249

3.  Monoclonal autoantibodies from insulin-dependent diabetic patients: autoantibodies against beta-cell surface or cytoplasmic antigens.

Authors:  E Houssaint; S Pogu; M Ouary; P Sai
Journal:  Clin Exp Immunol       Date:  1990-10       Impact factor: 4.330

4.  Multiple organ-reactivity of monoclonal autoantibodies to mouse erythrocytes.

Authors:  C Garzelli; F Basolo; C Puglisi; A Pacciardi
Journal:  Experientia       Date:  1987-08-15

5.  Probing the human B-cell repertoire: isolation of Epstein-Barr virus (EBV)-transformed human B lymphocytes making antibodies with a common idiotope that have different antigen-binding specificities.

Authors:  Y Uchigata; B S Prabhakar; A L Notkins
Journal:  J Clin Immunol       Date:  1988-11       Impact factor: 8.317
  5 in total

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