Literature DB >> 30095141

Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells.

Le Fang1, Giuseppe Trigiante, Christina J Kousseff, Rachel Crespo-Otero, Michael P Philpott, Michael Watkinson.   

Abstract

A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.

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Year:  2018        PMID： 30095141     DOI： 10.1039/c8cc05425h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Diketopyrrolopyrrole-based fluorescence probes for the imaging of lysosomal Zn2+ and identification of prostate cancer in human tissue.

Authors:  Chenchen Du; Shibo Fu; Xiaohua Wang; Adam C Sedgwick; Wei Zhen; Minjie Li; Xinqiang Li; Juan Zhou; Zhong Wang; Hongyu Wang; Jonathan L Sessler
Journal:  Chem Sci       Date:  2019-05-01       Impact factor: 9.825

Review 2.  Subcellular localised small molecule fluorescent probes to image mobile Zn2.

Authors:  Le Fang; Michael Watkinson
Journal:  Chem Sci       Date:  2020-10-09       Impact factor: 9.825

3.  Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2.

Authors:  Le Fang; Giuseppe Trigiante; Rachel Crespo-Otero; Chris S Hawes; Michael P Philpott; Christopher R Jones; Michael Watkinson
Journal:  Chem Sci       Date:  2019-10-16       Impact factor: 9.825
  3 in total

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