| Literature DB >> 30095060 |
Iván Flores-Ramírez1,2, Noemi Baranda-Avila2, Elizabeth Langley2.
Abstract
Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties and mechanisms of regulation have become the focus of intense research due to their intrinsic resistance to conventional cancer therapies. This review describes breast cancer stem cell origin, signaling pathways involved in self-renewal, such as Wnt, Notch and Hedgehog, biomarkers linked to stemness, and the role of sex steroid hormones in BCSC regulation. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: Breast cancer; biomarkers; breast cancer stem cells; estrogen receptor; progesterone receptor ; signaling pathways.
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Year: 2019 PMID： 30095060 DOI： 10.2174/1574888X13666180810121415
Source DB: PubMed Journal: Curr Stem Cell Res Ther ISSN： 1574-888X Impact factor: 3.828